Patients with Helicobacter pylori positive and negative duodenal ulcers have distinct clinical characteristics

Table 1 Concomitant medical problems.

Concomitant medical problems	Number of patients (%)
Hypertension	279 (20.8)
Diabetes mellitus	127 (9.5)
Ischemic heart disease	79 (5.9)
Cerebral vascular accidents	62 (4.6)
Rheumatic diseases	54 (4.0)
Chronic obstructive airway disease	34 (2.5)
Congestive heart failure	27 (2.0)
Chronic renal failure	26 (1.9)
Cirrhosis	21 (1.6)
Asthma	18 (1.3)

Table 2 Nature of recent surgery.

Type of operation	Number of patients
Orthopedic	12
Cardiothoracic	10
Colorectal	5
Urology	4
Neurosurgery	1
Hepatobiliary	1
Head and neck	1
Vascular	1
Appendicectomy	1
Gynecology	1
Endocrine	1
Ophthalmology	1

Table 3 Characteristics of patients according to their H pylori status.

Characteristics	H pylori negative (n = 398)	H pylori positive (n = 945)	P
Sex (M/F)	268/130	693/252	<0.03
Age (yr)	65.3±0.9	50.3±0.6	<0.0011
Concomitant medical problem (%)	50.8	24.1	<0.0011
Pre-existing malignancy (%)	10.3	2.5	<0.0011
Recent surgery (%)	8.0	0.7	<0.0011
Recent sepsis (%)	5.0	0	<0.0011
NSAIDs usage (%)	13.1	5.3	<0.0011
Aspirin usage (%)	7.3	4.0	0.019
Corticosteroid usage (%)	0.8	0.1	0.08
Smoking (%)	18.1	25.6	0.003
Drinking (%)	3.5	5.0	0.315

¹Significant factors on multivariate analysis.

Table 4 Relationship of H pylori status and concomitant medical problem.

Concomitant medical problem (%)	H pylori negative (n = 398)	H pylori positive (n = 945)	P
Hypertension	30.7	16.6	<0.001
Diabetes mellitus	15.3	7.0	<0.001
Ischemic heart disease	10.0	4.1	<0.001
Rheumatic diseases	7.8	2.4	<0.001
Cerebral vascular accidents	7.3	3.5	<0.005
Congestive heart failure	5.8	0.4	<0.001
Chronic renal failure	5.8	0.3	<0.001
Chronic obstructive airway disease	5.5	1.3	<0.001
Cirrhosis	4.0	0.5	<0.001
Asthma	1.0	1.5	NS

Table 5 Clinical presentations of patients according to their H pylori status.

Presentations	H pylori negative (n = 398)	H pylori positive (n = 945)	P
Presenting symptom
Presenting symptom Pain	59	190
Bleeding	335	753
Obstruction	4	2	<0.02
Multiple ulcers (%)	10.6	3.6	<0.001
Ulcer size (cm)	1.2±0.04	0.9±0.02	<0.001