Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats

Table 1 Effect of MSCs on levels of fibrosis index of rats induced with CCl₄.

Group	n	HA (mg/L)	LN (mg/L)	TBIL (mg/L)	ALT (U/L)	Hyp (mg/g)
Paraffin/saline	10	167.5±25.8b	54.2±13.2b	8.8±3.5b	46.8±7.9b	650±130b
CCl4×6 wk	10	883.5±109.6	224.2±56.2	22.8±5.9	132.7±42.9	2500±330
CCl4/saline	8	783.5±89.6	215.8±61.9	21.6±5.5	110.1±58.3	2100±430
CCl4/MSCs	9	454.1±98.8b	85.2±43.9b	9.8±6.3b	51.3±11.9b	1150±510b

^bP<0.01 vs CCl₄/saline. Not significantly different between values of CCl₄/saline and CCl₄×6 wk.

Table 2 Effect of MSCs on levels of fibrosis index of rats induced with DMN.

Group	n	HA (mg/L)	LN (mg/L)	TBIL (mg/L)	ALT (U/L)	Hyp (mg/g)
Saline	10	142.3±18.9a	44.5±16.4a	5.1±1.5a	32.7±6.8a	450±110a
DMN10	10	338.7±60.3a	82.3±23.5a	8.7±1.8a	85.3±12.5a	760±210a
DMN20	10	583.5±59.6a	114.9±44.2a	10.8±3.5a	162.7±22.7a	1250±450a
DMN10/saline	4	981.4±110.5	214.2±56.5	21.6±5.5	212.1±51.4	2250±650
DMN10/MSCs	8	395.2±43.1ab	83.1±43.1ab	9.1±4.7ab	67.7±32.9ab	1010±580ab
DMN20/MSCs	6	517.8±82.6a	98.2±57.2a	11.1±6.2a	89.7±38.6a	1150±750a

^aP<0.05 vs DMN20/MSCs,

^bP<0.01 vs DMN10/saline respectively.