Lethal effect and apoptotic DNA fragmentation in response of D-GalN-treated mice to bacterial LPS can be suppressed by pre-exposure to minute amount of bacterial LPS: Dual role of TNF receptor 1

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Jun 14, 2005 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2005; 11(22): 3398-3404
Published online Jun 14, 2005. doi: 10.3748/wjg.v11.i22.3398

Table 1 Effect of LPS pretreatment on the lethality and DNA fragmentation induced by LPS/D-GalN in TNFR2-/- mice.

LPS pretreatment (0.1 mg) before challenge (h)	Challenge: LPS (0.05 mg) + D-GalN (20 mg)
LPS pretreatment (0.1 mg) before challenge (h)	Lethality (dead/total)	DNA fragmentation
None	5/5	+
24	0/5	-
18	0/5	-
3	0/5	-
1.25	0/5	-

+, fragmentation present; -, fragmentation absent.

Citation: Zhou BR, Gumenscheimer M, Freudenberg MA, Galanos C. Lethal effect and apoptotic DNA fragmentation in response of D-GalN-treated mice to bacterial LPS can be suppressed by pre-exposure to minute amount of bacterial LPS: Dual role of TNF receptor 1. World J Gastroenterol 2005; 11(22): 3398-3404
URL: https://www.wjgnet.com/1007-9327/full/v11/i22/3398.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i22.3398