Effect of emodin on small intestinal peristalsis of mice and relevant mechanism

Table 1 Effect of emodin on charcoal powder propelling movement of small intestine in mice (mean±SD, n = 10).

Group	Dose (g/kg)	Charcoal powder propelling ratio (%)
Normal control	—	56.4±4.9
Model	—	44.7±10.3d
Emodin low dose	0.1	54.6±6.6a
Emodin medium dose	0.2	67.2±18.4b
Emodin high dose	0.4	70.6±10.1b

^aP<0.05 vs model;

^bP<0.01 vs model;

^dP<0.01 vs normal control.

Table 2 Effect of emodin (glucose-free K-H) on transmural potential difference (PD) of mice in vitro (mean±SD, n = 10).

Group	Concentration (g/L)	PD (mV)
		Before administration	15 min after administration
K-H solution		2.43±0.43	2.25±0.39
Emodin	0.2	2.15±0.58	2.02±0.50
	0.4	2.42±0.40	2.28±0.52
	0.8	2.55±0.34	2.52±0.32
	1.6	2.38±0.21	2.23±0.27

Table 3 Effect of emodin on the activity of Na⁺–K⁺-ATPase in small intestinal mucosa of mice (mean±SD, n = 10).

Group	Dose (mg/kg)	Activity of Na+-K+-ATPase (mmol pi/mg Pro/h)
Normal control	—	15.82±3.29
Model	—	20.84±4.29d
Emodin low dose	0.1	17.41±2.56a
Emodin medium dose	0.2	16.57±1.74b
Emodin high dose	0.4	16.20±2.09b

^aP<0.05,

^bP<0.01 vs model;

^dP<0.01 vs normal control.