MR diffusion-weighted imaging of rabbit liver VX-2 tumor

Table 1 Results of rabbit VX-2 tumor implant.

Methods	Number	Success of implant	Postoperative infection	Postoperative death	Cause of death	Rate of success (%)
Pre-experiment
Intraderm	14	4	0	4	Diarrhea	29 (4/14)
Intrahepatic	6	2	0	2	Diarrhea	33 (2/6)
Experiment
Intrahepatic	12	10	0	1	Diarrhea	83 (10/12)

Table 2 ADC values of normal rabbit liver and VX-2 tumor (mean±SD).

	ADC values	A1	B1	C1	D1	F	P
A1	2.57±0.26		P<0.012	P<0.012	P<0.012
B1	1.73±0.31	P<0.01
C1	1.87±0.25	P<0.01			P<0.052
D1	1.57±0.23	P<0.01		P<0.052
ANOVA						43.26	P<0.01

¹A – normal rabbit liver DWI (b = 100 s/mm2); B – normal rabbit liver DWI (b = 300 s/mm2); C – VX-2 tumor DWI (b=100 s/mm2); D – VX-2 tumor DWI b=100 s/mm2);

²Difference between different b-value groups or between normal liver parenchyma group and VX-2 tumor group.

Table 3 Progression of intrahepatically implanted VX-2 tumor in 12 rabbits.

No.	Common conditions1						Transferring conditions2 (MRI and autopsy)								Survival time(d)
	7 d	14 d	21 d	28 d	35 d	40 d	A	B	C	D	E	F	G	H3
1	1	1	2	4			+	+	+	–	–	–	–	–	28
2	1	1	2	3	3	3	–	+	–	–	+	–	–	–	>40
3	1	1	3	3	3	4	+	+	+	–	–	–	+	–	39
4	4						–	–	–	–	–	+	–	–	3
5	1	1	1	1	1	1	–	–	–	–	–	–	–	–	>40
6	2	1	2	3	3	3	+	+	+	–	+	–	–	–	>40
7	1	1	1	3	4		–	+	–	–	–	+	+	–	33
8	3	2	3	3	3	3	+	+	+	–	+	–	–	–	>40
9	1	1	2	3	3	4	+	+	+	–	+	–	+	–	38
10	1	1	2	3	4		–	+	+	–	–	–	+	–	32
11	1	2	3	3	3	3	–	+	–	–	+	–	–	–	>40
12	1	1	3	3	3	4	+	+	+	–	+	–	+	–	39

¹Common conditions: 1 – well; 2 – common; 3 – bad; 4 – dead.

²Transferring or metastasizing conditions:– no transferring or metastasizing; + transferring or metastasizing.

³A – liver; B – lung; C – mediastina; D – brain; E – thoracic or abdominal cavity; F – postperitone; G – diaphragm and heart; H – kidney or pancreas.