Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population

Table 1 Frequency distributions and odds ratios of multiple risk factors in 507 HCC cases and 541 controls.

Risk factor	Variable	HCC case	Control	Crude	Adjusted	P
		n (%)	n (%)	OR (95% CI)	OR (95% CI)1
p53 Arg72Pro	Arg	563 (55.5)	646 (59.7)	1
	Pro	451 (44.5)	436 (40.3)	1.19 (1.00-1.41)		0.05
	Arg/Arg	145 (28.6)	188 (34.8)	1	1
	Arg/Pro	273 (53.8)	270 (49.9)	1.31 (1.00-1.73)	1.21 (0.82-1.78)	0.34
	Pro/Pro	89 (17.6)	83 (15.3)	1.39 (0.96-2.01)	1.79 (1.06-3.01)	0.03
Sex	Female	73 (14.4)	278 (51.4)	1	1
	Male	434 (85.6)	263 (48.6)	6.28 (4.66-8.48)	4.97 (3.28-7.52)	<0.001
Cigarette smoking	No	288 (56.8)	437 (80.8)	1	1
	Yes	219 (43.2)	104 (19.2)	3.20 (2.42-4.21)	1.90 (1.19-3.02)	<0.01
Alcohol drinking	No	304 (60.0)	446 (82.4)	1	1
	Yes	203 (40.0)	95 (17.6)	3.13 (2.36-4.16)	1.20 (0.75-1.93)	0.44
HBsAg	Negative	137 (27.0)	445 (82.3)	1	1
	Positive	370 (73.0)	96 (17.7)	12.52 (9.32-16.82)	16.83 (11.53-24.56)	<0.001
Anti-HCV	Negative	469 (92.5)	527 (97.4)	1	1
	Positive	38 (7.5)	14 (2.6)	3.05 (1.63-5.69)	7.29 (3.17-16.80)	<0.001
Family history2	No	433 (85.4)	532 (98.3)	1	1
	Yes	74 (14.6)	9 (1.7)	10.07 (5.00-20.33)	9.47 (3.92-22.90)	<0.001

¹All the variables in the table and age were included in the logistic regression model; ²Family history of HCC in first-degree relatives.