Six-year follow-up of pancreatic β cell function in adults with latent autoimmune diabetes

Table 1 Baseline data of LADA1, two group and T2DM1, two group (mean±SD).

	LADA1	T2DM1	LADA2	T2DM2
Number	16	16	29	29
Sex (male/female)	11/5	12/4	18/11	19/10
Age (yr)	47.7±11.2	47.0±7.9	49.0±12.0	52.2±10.9
Age at onset (yr)	44.9±10.5	44.2±7.4	46.0±11.1	49.9±10.1
Duration (yr)	2.7±0.9	2.8±0.5	3.0±0.6	2.2±0.4
BMI (kg/m2)	20.7±2.9	21.8±1.7	21.4±3.3	22.5±1.9
FBG (mmol/L)	14.5±5.3	13.7±1.7	14.2±5.6	13.5±3.1
HbA1c (%)	10.1± 0.6	9.9±1.9	9.2±2.2	8.6±2.0
Family history (%)	18.8	12.5	10.3	10.3
Insulin therapy (%)FCP (pmol/L)	56.3 (9/16)	37.5 (6/16)	65.5 (19/29)	51.7 (15/29)
Postprandial-2-h	572.8±72.3	714.6±63.7	531.3±53.2b	772.7±86.1
C-peptide (pmol/L)	885.1±147.7a	1196.7±104.2	1240.0±140.5b	1659.9±188.5

^aP<0.05 vs T2DM group,

^bP<0.01 vs T2DM group.

Table 2 Correlation analysis of the average decreased percentages of FCP per year in LADA patients.

	GAD-Ab Index	Age at onset (yr)	BMI (kg/m2)	Sex (m/f)	Duration (yr)	Family history	FBG (mmol/L)	HbA1c (%)
Correlation efficient	0.408	–0.301	–0.523	0.19	–0.084	–0.198	0.132	–0.035
P	0.006	0.047	0.000	0.216	0.590	0.197	0.430	0.835

The correlations between variables at entry including GAD-Ab index, age at onset, BMI, sex, duration, family history, FBG, HbA1c and the average decreased percentages of FCP per year in LADA patients were analyzed. And GAD-Ab index, age at onset and BMI were found to be the three significant variables (r = 0.408, -0.301 and -0.523, P = 0.006, 0.047 and 0.000).