Combined effects of Cantide and chemotherapeutic drugs on inhibition of tumor cells’ growth in vitro and in vivo

Table 1 IC₅₀ of chemotherapeutic drugs only or that of combination treatments (μg/mL).

Tumor cell lines	Chemotherapeuticdrugs	Concentration of Cantide (mmol/L)
		0.0	0.1	0.2	0.4
	DDP	0.45	0.36	0.27	0.15
BGC	5-FU	10.28	7.84	2.17	1.70
	ADM	0.60	0.43	0.38	0.11
	DDP	5.43	3.21	2.04	0.96
A549	5-FU	9.69	9.06	5.34	0.31
	ADM	0.76	0.71	0.60	0.43

Table 2 Tumor weights after treatment.

Group	Tumor weight (g)	Inhibitory rate (%)
Control	2.17±0.31	0.0
Cantide	1.05±0.16	51.6
DDP	1.13±0.09	47.9
Cantide+DDP	0.65±0.19	70.0

Cantide+DDP group is significantly different from any group treated with a single drug: P = 0.0009<0.001 vs Cantide group; P = 0.0001<0.001 vs DDP group (t test). The results are expressed as mean±SD of 7-8 mice per group.