Clinical Research
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Apr 28, 2005; 11(16): 2456-2461
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2456
Table 1 Diseases and surgical techniques.
DiseasesNo. of patients(n = 62)Surgical techniques
PD (n = 52)PPPD (n = 10)
Pancreas cancer29263
Ampullary cancer14104
Bile duct cancer13121
Islet cell cancer211
Duodenal cancer110
Chronic pancreatitis110
Pancreatic cystadenoma101
Gastric cancer110
Table 2 General risk factors for pancreatic leakage [n (%)].
ParametersLeakage group Parameters (n = 12)Nonleakage group(n = 45)P
Age (yr)59.8±10.0457.1±11.370.487
Gender0.166
Male4 (10.5)134 (89.5)1
Female6 (25)118 (75)1
History of jaundice0.733
Yes4 (13.3)126 (86.7)1
No6 (18.8)126 (81.2)1
Preoperative
serum-albumin>0.95
Normal10 (16.9)149 (83.1)1
Low0 (0)13 (100)1
Pathology0.3122
Pancreas cancer3 (10.3)126 (89.7)1
Ampullary cancer3 (21.4)111 (78.6)1
Bile duct cancer3 (23.1)110 (76.9)1
Islet cell tumor1 (50)11 (50)1
Duodenal cancer0 (0)11 (100)1
Chronic pancreatitis0 (0)11 (100)1
Pancreatic
cystadenoma0 (0)11 (100)1
Gastric cancer0 (0)1 (100)
Octreotide0.493
Used6 (20.7)123 (79.3)1
Non-used4 (12.1)129 (87.9)1
Postoperative stay (d)32.7±12.3726.4±13.510.177
Table 3 Intraoperative risk factors for pancreatic leakage [n (%)].
ParametersLeakage group (n = 12)Nonleakage group (n = 45)P
Type of resection0.629
PD8 (15.1)145 (84.9)1
PPPD2 (22.2)17 (87.8)1
Anastomotic technique0.43
Duct-to-mucosa1 (6.25)115 (93.75)1
Invagination9 (19.6)137 (80.4)1
Pancreatic size (mm)0.002
≥32 (4.88)139 (95.12)1
<38 (38.1)113 (61.9)1
Pancreatic texture0.004
Hard1 (2.94)133 (97.06)1
Soft9 (32.1)119 (67.9)1
Operative time (h)7.052.406.342.020.325
Intraoperative
blood loss (mL)2400 (0, 1250)350 (0, 1 200)0.352
Table 4 Multivariate logistic regression for pancreatic leakage.
ParametersPOdds ratioCI
Anastomotic
technique
Duct-to-mucosa-1
Invagination0.1289.9670.514-193.15
Pancreatic size (mm)
≥3-1
<30.00711.8671.96-71.86
Pancreatic texture
Hard-1
Soft0.01715.4451.629-146.46