Effects of total glucosides of peony on immunological hepatic fibrosis in rats

Table 1 Effect of TGP on serum ALT, AST activities and A/G value in immunological hepatic fibrosis rat induced by human albumin. (n = 8, mean±SD).

Groups	Doses (mg/kg)	ALT (U/L)	AST (U/L)	A/G
Normal	-	54.63±22.50	61.47±27.81	1.17±0.31
Model	-	78.79±15.03	94.51±37.30	0.90±0.19
TGP	60	75.67±22.50	82.25±17.33	0.92±0.21
	120	70.61±24.62	75.43±26.94	0.96±0.17
Colchicine	0.1	77.71±27.64	78.99±22.24	0.93±0.18

Table 2 Effect of TGP on the pathologic grading of immunological hepatic fibrosis rat induced by human albumin. (n = 10, mean±SD).

Group	Dose(mg/kg)	Pathologic grading of hepatic fibrosis					P
		0	I	II	III	IV
Normal	–	10	0	0	0	0	–
Model	–	0	0	3	3	4	0.000d
TGP	60	0	2	5	2	1	0.043a
	120	0	4	4	2	0	0.006b
Colchicine	0.1	0	3	4	3	0	0.016a

^aP<0.05,

^bP<0.01 vs model group;

^dP<0.01 vs normal control group.

Table 3 Effect of TGP on plasma LN and PC III level in immunological hepatic fibrosis rat induced by human albumin. (n = 8, mean±SD).

Groups	Doses (mg/kg)	LN (mg/L)	PC III (mg/L)
Normal	---	106.9±25.4	74.4±25.9
Model	---	228.0±76.2d	294.1±99.2d
TGP	60	142.1±39.8a	174.7±69.5
	120	127.1±26.8b	148.5±68.6a
Colchicine	0.1	112.6±27.7b	121.6±32.6b

^aP<0.05,

^bP<0.01 vs model group;

^dP<0.01 vs normal control group.

Table 4 Effects of TGP on MDA levels, SOD and GSH-px activities liver homogenates in of immunological hepatic fibrotic rats (n = 10, mean±SD).

Groups	Doses(mg/kg)	MDA (nmol/mg pr)	SOD (U/mg pr)	GSH-Px (U/mg pr)
Normal	-	1.88±0.73	142.33±41.00	101.00±28.70
Model	-	4.34±1.12d	81.95±26.48d	50.64±15.28d
TGP	60	2.41±0.85b	116.95±32.18	73.70±16.60
	120	2.21±0.89b	136.53±36.15a	83.64±26.16a
Colchicine	0.1	3.02±0.68a	101.19±44.47	69.80±23.65

^aP<0.05,

^bP<0.01 vs model group;

^dP<0.01 vs normal control group.