Genetic distinctions between autoimmune hepatitis in Italy and North America

doi:10.3748/wjg.v11.i12.1862

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Mar 28, 2005 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2005; 11(12): 1862-1866
Published online Mar 28, 2005. doi: 10.3748/wjg.v11.i12.1862

Table 1 Clinical and biochemical parameters of the studied groups at baseline.

Features	Italian type 1 AIH (57 patients)	Italian type 2 AIH (17 patients)	North American type 1 AIH (149 patients)
Gender (m/f)	7/50	2/15	27/122
Age (yr)	38 (15–76)	18 (8–34)	47 (13–81)
AST (×UNL)	10.9 (0.5–56)	4.7 (1.5–5.1)	9.5 (0.5–66)
ALP (×UNL)	1.1 (0.2–4.56)	1.5 (0.6–4.4)	0.91 (0.6–6)
Bilirubin (mg/dL)	1.3 (0.2–26)	3.8 (0.9–4.3)	1.9 (0.3–29)
Albumin (g/L)	37 (24–46)	40 (19–48)	32 (15–42)
g-Globulin (g/L)	23 (10–59)	22 (13–48)	29 (4–62)
IgG (mg/dL)	2592 (1 260–6 948)	2600 (1 530–4 212)	2460 (248–7 200)
IgA (mg/dL)	301 (40–963)	346 (30–643) 2	90 (6–1 870)
IgM (mg/dL)	200 (75–597)	307 (150–577)	228 (28–1 400)
ANA positivity	34 (60%)	0	113 (76%)
SMA positivity	44 (77%)	0	111 (74%)
LKM1 positivity	0	16 (94%)	0
LC1 positivity	0	4 (23%)	Not tested

Data are shown as the median value (range). AST: serum aspartate aminotransferase level. ALP: serum alkaline phosphatase level. ANA: anti-nuclear antibodies. SMA: smooth muscle antibodies. LKM1: liver kidney microsome antibodies type 1. LC1: liver cytosol antibodies.

Table 2 Comparison of class I and class II HLA in Italian patients and controls (n, %).

HLA	Type 1 AIH (57 cases)	Type 2 AIH (17 cases)	Controls (250 BD)	P_I	P_II	P_III
B8	18 (32)	3 (18)	138 (10)	<0.0001	NS	NS
C7	29 (51)	7 (41)	270 (20)	<0.0001	NS	NS
DR3	17 (30)	5 (29)	32 (13)	0.004	NS	NS
DR4	13 (23)	4 (23)	41 (16)	NS	NS	NS
DR7	9 (16)	6 (35)	72 (29)	NS	NS	NS
DR11	10 (17)	7 (41)	87 (35)	0.01	NS	NS
DR13	15 (26)	1 (6)	65 (23)	NS	NS	NS
DQ2	30 (53)	9 (53)	75 (30)	<0.0001	NS	NS
B8–DR3–DQ2	17/57 (30)	2 (12)	323 (7)	<0.0001	NS	NS

Test used: Fisher’s exact test. AIH: autoimmune hepatitis. BD: blood donors. P_I: type 1 AIH vs controls, P_II: type 2 AIH vs controls, P_III: type 1 AIH vs type 2 AIH. ¹Evaluated on a sample of 372 controls. ²Evaluated on a sample of 350 controls. ³Evaluated on a sample of 337 controls.

Table 3 Comparison between Italian and North American AIH patients.

HLA	Italian type 1 AIH (57 cases)	North American type 1 AIH (n = 149)	Italian type 2 AIH (17 cases)
B8	18 (32)^a	73 (49)^a	3 (18)^a
DR3	17 (30)^a	77 (52)^a	5 (29)
DR4	13 (23)^a	64 (43)^a	4 (23)
DR7	9 (16)	23 (15)	6 (35)
DR11	10 (18)^a	11 (7)^a^c	7 (41)^c
DR13	15 (26)	24 (16)	1 (6)
DQ2	30 (53)	84 (57)	9 (53)
B8–DR3–DQ2	17 (30)^a	70 (48)^a^c	2 (12)^c

^aP<0.05,

^cP<0.005. Evaluation on a sample of 146 patients.

Citation: Muratori P, Czaja AJ, Muratori L, Pappas G, Maccariello S, Cassani F, Granito A, Ferrari R, Mantovani V, Lenzi M, Bianchi FB. Genetic distinctions between autoimmune hepatitis in Italy and North America. World J Gastroenterol 2005; 11(12): 1862-1866
URL: https://www.wjgnet.com/1007-9327/full/v11/i12/1862.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i12.1862