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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Mar 28, 2005; 11(12): 1843-1847
Published online Mar 28, 2005. doi: 10.3748/wjg.v11.i12.1843
Published online Mar 28, 2005. doi: 10.3748/wjg.v11.i12.1843
Table 1 Baseline characteristics and biochemical markers in non-cirrhotic hepatitis B or C patients.
| Parameter | All patients (n = 43) | Hepatitis B(n = 13) | Hepatitis C (n = 30) |
| Age (yr) | 49 (26–77) | 49 (27–67) | 49 (26–77) |
| BMI (kg/m2) | 23.32 (18.42–32.45) | 23.33 (19.44–30.35) | 23.32 (18.42–32.45) |
| Males, n (%) | 12 (28) | 6 (46) | 6 (20) |
| Osteoporosis (%) | 8 (19) | 2 (15) | 6 (20) |
| Osteopenia (%) | 25 (58) | 7 (54) | 18 (60) |
| Smoking, n (%) | 6 (14) | 4 (31) | 2 (7) |
| Diagnosis, n (%) | 13 (30) | 30 (70) | |
| HBV-DNA (log copies/mL) | 2.46 (1.00–7.70) | ||
| HCV-RNA (log IU/mL) | 5.46 (1.00–5.93) | ||
| Staging1 | |||
| Low grade 1–2 | 32 (82) | 9 (82) | 23 (82) |
| High grade 3–4 | 7 (18) | 2 (18) | 5 (18) |
| ALT (mmol/L s) | 0.70 (0.14–1.58) | 0.55 (0.44–1.39) | 0.74 (0.14–1.58) |
| Albumin (g/L) | 42.2 (38.7–46.8) | 41.8 (39.8–46.8) | 42.1 (38.7–45.5) |
Table 2 Characteristics of bone metabolism in patients with chronic viral liver disease.
| Parameter | All patients (n = 43) | Hepatitis B (n = 13) | Hepatitis C (n = 30) |
| AlkPhos (mmol/L s) | 2.95 (1.32–10.87) | 2.39 (1.96–6.67) | 2.98 (1.32–10.87) |
| BALP (mmol/L s) | 1.69 (0.76–3.89) | 1.52 (0.76–2.94) | 1.51 (0.76–3.89) |
| iPTH (pmol/L) | 2.57 (1.35–5.96) | 2.59 (1.35–5.96) | 2.69 (1.45–5.38) |
| 25 (OH)D3 (pg/mL) | 27.4 (11.9–65.7) | 27.40 (15.40–60.20) | 28.05 (11.90–65.70) |
| 1,25 (OH)2D3 (pg/mL) | 38.7 (10.0–86.8) | 41.40 (21.50–60.7) | 38.20 (10.00–86.80) |
| Phosphate (mmol/L) | 1.08 (0.57–1.43) | 0.95 (0.57–1.15) | 1.09 (0.67–1.43) |
| Ca (mmol/L) | 2.43 (2.17–2.58) | 2.44 (2.22–2.58) | 2.39 (2.17–2.57) |
| iCa (mmol/L) | 1.23 (0.99–1.34) | 1.22 (1.12–1.29) | 1.25 (0.99–1.34) |
| PD/UCr (pmol/µmoL) | 58.0 (30.0–235.0) | 59.0 (30.0–102.0) | 57.00 (34.00–235.00) |
| DPD/UCr (pmol/mmoL) | 13.3 (6.3–50.5) | 10.6 (6.3–26.7) | 13.85 (6.4–50.5) |
Table 3 Correlation of liver histology (staging) with bone markers in patients with chronic hepatitis B or C.
| Parameter | r | P |
| iPTH | 0.523 | 0.001 |
| 25 (OH)D3 | –0.025 | 0.878 |
| 1,25 (OH)2D3 | 0.006 | 0.973 |
| Phosphate | –0.033 | 0.841 |
| iCa | –0.215 | 0.188 |
| BALP | 0.469 | 0.001 |
Table 4 Correlation of BMD femoral neck with bone markers and vitamin D in patients with chronic viral hepatitis.
| Parameter | r | P |
| iPTH | 0.325 | 0.02 |
| 25 (OH)D3 | 0.282 | 0.067 |
| 1,25 (OH)2D3 | –0.071 | 0.649 |
| Phosphate | –0.204 | 0.057 |
| iCa | 0.022 | 0.888 |
| BALP | –0.082 | 0.599 |
- Citation: Schiefke I, Fach A, Wiedmann M, Aretin AV, Schenker E, Borte G, Wiese M, Moessner J. Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection. World J Gastroenterol 2005; 11(12): 1843-1847
- URL: https://www.wjgnet.com/1007-9327/full/v11/i12/1843.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i12.1843