Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma

Table 1 Correlation of treatment response of various parameters. Various parameters of eight cell lines were determined after treatment with single agents and/or combinations. The response-pattern of parameters was investigated for correlation.

	HLA-ABC	HLA-DR	HLA-ABC mean	HLA-DR mean	CD 21	CD 118	EGF-R	Fas	FasL	VEGF	Proliferation index	Apoptosis/necrosis	Cell survival index
HLA-ABC
Pearson’s correlation		0.928	0.783	0.777	-0.907	0.790	-0.769	0.887	0.867			-0.825
P		0.001	0.012	0.014	0.001	0.011	0.015	0.001	0.002	NS	NS	0.006	NS
HLA-DR
Pearson’s	0.928		0.71	0.743	-0.753			0.762	0.782			-0.705
P	0.001		0.032	0.022	0.019	NS	NS	0.017	0.013	NS	NS	0.034	NS
HLA-ABC mean
Pearson’s	783	0.71		0.939	-0.718		-0.892
P	0.012	0.032		0.001	0.029	NS	0.001	NS	NS	NS	NS	NS	NS
HLA-DR mean
Pearson’s	0.777	0.743	0.939				-0.738
P	0.014	0.022	0.001		NS	NS	0.023	NS	NS	NS	NS	NS	NS
CD 21
Pearson’s	-0.907	-0.753	-0.718			-0.926	0.85	-0.976	-0.957		-0.810	0.915
P	0.001	0.019	0.029	NS		0.001	0.004	0.001	0.001	NS	0.008	0.001	NS
CD 118
Pearson’s	0.79				-0.926			0.966	0.946	0.596	0.898	-0.936	0.718
P	0.011	NS	NS	NS	0.001		NS	0.0001	0.0001	0.158	0.001	0.001	0.029
EGF-R
Pearson’s	-0.769		-0.892	-0.738	0.850			-0.764	-0.758
P	0.015	NS	0.001	0.023	0.004	NS		0.017	0.018	NS	NS	NS	NS
Fas
Pearson’s	0.887	0.762			-0.976	0.966	-0.764		0.985		0.888	-0.922
P	0.001	0.017	NS	NS	0.0001	0.0001	0.017		0.001	NS	0.001	0.001	NS
FasL
Pearson’s	0.867	0.782			-0.957	0.946	-0.758	0.985			0.875	-0.886	0.675
P	0.002	0.013	NS	NS	0.001	0.001	0.018	0.001		NS	0.002	0.001	0.046
VEGF
Pearson’s 0.8
P	NS	NS	NS	NS	NS	NS	NS	NS	NS		0.031	NS	NS
Proliferation index
Pearson’s					-0.81	0.898		0.888	0.875	0.800
P	NS	NS	NS	NS	0.008	0.001	NS	0.001	0.002	0.031		NS	NS
Apoptosis/necrosis
Pearson’s	-0.825	-0.705			0.915	-0.936		-0.922	-0.886		-0.721		-0.748
P	0.006	0.034	NS	NS	0.001	0.001	NS	0.001	0.001	NS	0.028		0.020
Cell survival index
Pearson’s						0.718			0.675			-0.748
P	NS	NS	NS	NS	NS	0.029	NS	NS	0.046	NS	NS	0.020

NS = not significant.