E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population

Table 1 Distribution of selected characteristics of gastric cancer patients and cancer-free controls.

Variable	Cases (n = 206)		Controls (n = 261)		P value1
	n	%	n	%
Age (yr)
≤60	89	43.2	114	43.7
>60	117	56.8	147	56.3	0.918
Sex
Male	150	72.8	190	72.8
Female	56	27.2	71	27.2	0.996
Alcohol status
Nondrinker	118	57.3	136	52.1
Drinker	88	42.7	125	47.9	0.265
Smoking status2
Nonsmoker	84	40.8	100	38.6
Smoker	122	59.2	159	61.4	0.635
H pylori infection3
Negative	91	44.2	93	35.9
Positive	115	55.8	166	64.1	0.07
Daily drinking of tea
Yes	77	37.4	123	47.1
No	129	62.6	138	52.9	0.035
Family history of gastric cancer4
Yes	42	20.5	25	9.6
No	163	79.5	235	90.4	0.001

¹Two-side χ² test; ²Two controls missed smoking information; ³Two controls missed H pylori information; ⁴One case and one control missed information of family history.

Table 2 CDH1 genotype frequencies of patients and control subjects and their association with gastric cancer.

Genotype	Cases (n = 206)		Controls (n = 261)		OR (95%CI)1
	n	%	n	%
CC	119	57.8	152	58.22	1
CA	75	36.4	91	34.9	1.15 0.78-1.72
AA	12	5.8	18	6.9	0.90 0.40-2.01
	χ2 = 0.29	P = 0.87
CC	119	57.8	152	58.2	1
CA+AA	87	42.2	109	41.8	1.05 0.72-1.54
	χ2 = 0.01	P = 0.92
C allele	395	75.7	313	76	1
A allele	127	24.3	99	24	1.02 0.75-1.37
	χ2 = 0.01	P = 0.92

¹ORs were adjusted for age, sex, smoking, alcohol drinking, residence, tea consumption, H pylori infection and family history of gastric cancer in a logistic regression model; ²The observed genotype frequency (CC, CA and AA) in the control subjects was in agreement with Hardy-Weinberg equilibrium (p2+2pq+q2 = 1) (χ² = 0.738, P = 0.69).

Table 3 Stratification analyses of CDH1 genotype frequencies, ORs and 95% CIs in gastric cancer.

Variables	Cases		Controls		OR (95%CI)1
	CC n (%)	CA+AA n (%)	CC n (%)	CA+AA n (%)
Total	119 (57.7)	87 (42.2)	152 (58.2)	109 (41.8)
Age (yr)
≤60	53 (59.6)	36 (40.4)	66 (57.9)	48 (42.1)	0.86 (0.47-1.56)
>60	66 (56.4)	51 (43.6)	86 (58.5)	61 (41.5)	1.20 (0.71-2.00)
Sex
Male	90 (60.0)	60 (40.0)	107 (56.3)	83 (43.7)	0.92 (0.58-1.44)
Female	29 (51.8)	27 (48.2)	45 (63.4)	26 (36.6)	1.81 (0.85-3.86)
Residence
Jin-tan	56 (59.0)	39 (41.0)	80 (55.2)	65 (44.8)	0.90 (0.52-1.57)
Huai-an	63 (56.8)	48 (43.2)	72 (62.1)	44 (37.9)	1.31 (0.76-2.27)
Smoking
No	54 (64.3)	30 (35.7)	58 (58.0)	42 (42.0)	0.79 (0.43-1.48)
Yes	65 (53.3)	57 (46.7)	93 (58.5)	66 (41.5)	1.31 (0.79-2.16)
Alcohol Drinking
No	71 (60.2)	47 (39.8)	88 (64.7)	48 (35.3)	1.27 (0.75-2.15)
Yes	48 (54.6)	40 (45.5)	64 (51.2)	61 (48.8)	0.92 (0.51-1.63)
H pylori infection
Negative	54 (59.3)	37 (40.7)	55 (59.1)	38 (40.9)	0.98 (0.53-1.80)
Positive	65 (56.5)	50 (43.5)	95 (57.3)	71 (36.7)	1.03 (0.63-1.71)
Family history of gastric cancer
No	94 (57.7)	69 (42.3)	138 (58.7)	97 (41.3)	1.07 (0.71-1.62)
Yes	24 (57.1)	18 (42.9)	14 (56.0)	11 (44.0)	1.40 (0.45-4.39)

¹ORs were adjusted for age, sex, smoking, alcohol drinking, residence, tea consumption, H pylori infection and family history of gastric cancer in a logistic regression model.