Clinicopathologic characteristics of gastric carcinoma in elderly patients: A comparison with young patients

Table 1 Clinicopathologic features of gastric carcinoma in the elderly and young patients.

Variables	Age > 70 yr (n = 194) (%)	Age < 36 yr(n = 137) (%)	P value
Age (yr)	73.3±3.1	30.6±5.1	<0.001
Gender			<0.001
Male	131 (67.5)	63 (46.0)
Female	63 (32.5)	74 (54.0)
Tumor size (cm)	5.16±3.45	5.07±3.23	NS
Number of lesions
Multiple	14 (7.2)	4 (2.9)	<0.05
Single	180 (92.8)	133 (97.1)
Borrmann type
I	10 (5.2)	5 (3.6)
II	43 (22.2)	13 (9.5)
III	128 (66.0)	93 (67.9)
IV	13 (6.6)	26 (19.0)	0.011
Location
Upper	16 (8.3)	23 (16.8)
Middle	41 (21.1)	50 (36.5)
Lower	130 (67.0)	56 (40.9)	<0.05
Whole	7 (3.6)	8 (5.8)
Depth of invasion NS
T1	37 (19.1)	27 (19.7)
T2	39 (20.1)	21 (15.3)
T3	96 (49.5)	73 (53.3)
T4	22 (11.3)	16 (11.7)
Histologic type
Well-differentiated	38 (19.5)	4 (2.9)
Moderately differentiated	62 (32.0)	15 (10.9)
Poorly differentiated	74 (38.1)	84 (61.3)	<0.001
Mucinous	10 (5.2)	4 (2.9)
Signet ring cell	6 (3.1)	25 (18.3)
Others	4 (2.1)	5 (3.7)
Nodal involvement			NS
N (-)	88 (45.4)	67 (48.9)
N (+)	106 (54.6)	70 (51.1)
Hepatic metastasis			NS
N (-)	188 (96.9)	132 (96.4)
N (+)	6 (3.1)	5 (3.6)
Peritoneal dissemination			NS
P (-)	176 (90.7)	116 (84.7)
P (+)	18 (9.3)	21 (15.3)
Stage			NS
1	60 (30.9)	41 (29.9)
2	41 (21.1)	21 (15.3)
3	55 (28.4)	36 (26.3)
4	38 (19.6)	39 (28.5)
Operative type
Total gastrectomy	52 (26.8)	47 (34.4)	0.004
Subtotal gastrectomy	122 (62.9)	78 (56.9)
Others	20 (8.6)	12 (8.7)
Resectability			NS
Curative	157 (80.9)	101 (73.7)

Table 2 Correlation between prognostic factors and survival rates of elderly patients with gastric carcinoma.

Variables	No. of patients (n = 194)	5-yr survival rate (%)	P value
Gender			0.3147
Male	131	43.3
Female	63	52.8
Tumor size (cm)
<5	102	66.8
>5	92	26
Depth of invasion			<0.001
T1 and 2	76	84.9
T3 and 4	118	20.6
Histologic type			0.0097
Differentiated	100	55.1
Undifferentiated	94	39.8
Tumor location			0.1969
Upper third	16	31.6
Middle/distal third	178	50.8
Operative type			<0.001
Total	52	27.9
Subtotal	142	55.5
LN invasion			<0.001
N0	88	77.9
N1	48	36.6
>N2	58	12.9

Table 3 Multivariate analysis of factors associated with elderly patients with gastric carcinoma.

Variables	Odds ratio	95% CI	P value
Gender (male vs female)	0.768	0.434-1.360	NS
Tumor location (upper vs distal)	0.467	0.231-0.944	NS
Tumor size (cm) (<5 vs >5)	1.618	0.942-2.778	NS
Depth of invasion (mucosa vs submucosa)	1.061	0.924-1.217	NS
Histologic type (differentiated vs undifferentiated)	2.041	1.244-3.350	0.005
Resectability (curative vs non-curative)	3.077	1.681-5.635	<0.001
Lymph node metastasis (negative vs positive)	3.626	1.985-6.622	<0.001
Age (yr) (>70 vs <70)	1.308	0.845-1.107	NS

CI: confidence interval, NS: not significant.