Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication

Table 1 Portal pressure and plasma aminotranferase levels

	Sham (I)	PH (II)	APAP (III)	PH + APAP (IV)
PP (mmHg)	8.5 ± 0.5	12.1 ± 1a	8.1 ± 0.2	11.9 ± 0.9a
AST (UI/L)	155 ± 25	316 ± 23b	426 ± 36b	380 ± 34b
ALT (UI/L)	39 ± 4	63 ± 9	134 ± 20a	308 ± 27b

Portal pressure (PP) was significantly increased in groups II and IV (^aP < 0.05 vs control and APAP group). AST plasma levels were significantly increased in groups II, III and IV (^bP < 0.001 vs sham group). ALT was significantly increased in groups III and IV (^aP < 0.05 and

^bP < 0.001 vs sham group, respectively).

Table 2 Rota rod test: First fall time

	Sham (I)	PH (II) APAP (III)		PH + APAP (IV)
Median	300a	3001	2051	451
CI (Lower 95%-Upper 95%)	(172-356)	(63-316)	(45-318)	(-13.9-108)a

¹expressed in seconds. Rota rod test was significantly different in group IV compared with all the others groups (^aP < 0.05 Dunnett´s test).