Effects of recombinant human growth hormone on remnant liver after hepatectomy in hepatocellular carcinoma with cirrhosis

Table 1 Patient characteristics

	PN group (n = 12)	rhGH + PN group (n = 12)
General conditions
Age (years)	46.1 ± 13.6	50.3 ± 10.6
Sex (M/F)	11/1	10/2
Body weight (kg)	59.7 ± 9.3	64.3 ± 7.7
Operative methods
Hepatic left lateral lobectomy	0	1
Left hemihepatectomy	2	2
Right hemihepatectomy	1	1
Tumor or segmentectomy	9	8
Intraoperative information
Operation time (min)	250.8 ± 126.4	203.3 ± 73.2
Intraoperative blood loss (mL)	1331.7 ± 1704.8	966.7 ± 1031.4
Intraoperative blood transfusion (mL)	1100.0 ± 1334.2	408.3 ± 609.7

Table 2 Comparison of liver function, blood glucose, serum prealbumin and transferrin

Normal control group (n = 12)		PN group (n = 12)			rhGH+PN group (n = 12)
		Preoperative	POD 1	POD 6	Preoperative	POD 1	POD 6
AST (IU/L)	26.0 ± 5	56.0 ± 27a	761.0 ± 578	62.0 ± 32	55.0 ± 25a	578.0 ± 206	56.0 ± 25
ALT (IU/L)	27.0 ± 17	60.0 ± 36a	749.0 ± 571	153.0 ± 95	42.0 ± 17a	590.0 ± 273	154.0 ± 71
ALP (IU/L)	94.0 ± 55	151.0 ± 87	145.0 ± 80	148.0 ± 65	105.0 ± 27	100.0 ± 33	113.0 ± 46
TBIL (µmol/L)	17.4 ± 6.4	22.6 ± 9.0	52.5 ± 48.1	43.1 ± 37.4	20.5 ± 9.3	42.1 ± 41.6	30.2 ± 21.0
ALB (g/L)	42.8 ± 4.0	39.8 ± 4.7	31.5 ± 3.3	34.0 ± 3.4	40.7 ± 3.5	32.4 ± 3.6	37.1 ± 5.0
Blood glucose (mmol/L)	4.6 ± 0.6	4.8 ± 0.9	7.3 ± 3.5	5.3 ± 1.5	4.5 ± 0.6	7.0 ± 3.2	8.8 ± 5.2c
Serum prealbumin (mg/L)	279.8 ± 43.0	202.4 ± 32.3a	158.3 ± 25.4	127.2 ± 13.4	204.5 ± 31.9a	157.2 ± 23.0	156.4 ± 20.0c
Serum transferrin (g/L)	3.5 ± 0.5	2.5 ± 0.2a	2.1 ± 0.3	1.8 ± 0.2	2.5 ± 0.2a	2.2 ± 0.3	2.2 ± 0.3c

^aP < 0.05, preoperative vs normal control group;

^cP < 0.05, between rhGH + PN group and PN group.

Table 3 Comparison of hepatic ALB mRNA and liver Ki67 labeling index

Normal control group (n = 12)		PN group (n = 12)			rhGH+PN group (n = 12)
		Tumor tissues	Adjacent non-tumor tissues	Liver biopsy specimens POD 6	Tumor tissue	Adjacent non-tumor tissues	Liver biopsy specimens POD 6
ALB mRNA	0.69 ± 0.05	0.38 ± 0.01a	0.50 ± 0.06ac	0.63 ± 0.05	0.38 ± 0.01a	0.50 ± 0.06ac	0.71 ± 0.06e
Liver Ki67 LI (%)	0	17.4 ± 6.1a	0.20 ± 0.1ac	4.60 ± 0.5	17.2 ± 5.9a	0.20 ± 0.1ac	5.50 ± 0.5e

^aP < 0.05, tumor tissues or adjacent non-tumor tissues vs normal control group;

^cP < 0.05, adjacent non-tumor tissues vs tumor tissues in the same group,

^eP < 0.05, of the same tissues comparison between the PN group and rhGH + PN group.