Basic Research
Copyright ©The Author(s) 2004.
World J Gastroenterol. Apr 1, 2004; 10(7): 1019-1027
Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.1019
Table 1 Changes in serum concentration of ALT and AST (n = 6, mean ± SD)
GroupAST (U/L)ALT (U/L)
C99.3 ± 13.261.90 ± 12.1
IR820.9 ± 111.3d762.80 ± 130.5d
IP407.7 ± 73.7b281.00 ± 35.6b
IR + PMA553.2 ± 58.67b354.37 ± 53b
IP + PD732.9 ± 91.1f466.20 ± 82.8f
IP + CHE678.6 ± 136.5f645.61 ± 90.4f
Table 2 Protection of hypoxic preconditioning against cytotox-icity caused by hypoxic hepatocyte incubation (n = 6, mean ± SD)
GroupHepatocyte viability (%)
C95 ± 10.8
HR35.57 ± 3.99b
HP81.49 ± 12.1d
HR + PMA75.29 ± 11.9d
HP + PD51.03 ± 9.09f
HP + CHE47.21 ± 5.42f
Table 3 Changes in levels of phosphorylation activity of PKC in the liver (n = 6, mean ± SD)
GroupPhosphorylation activity of PKC (fmol/mg/min)
C36.28 ± 3.8
IR42.78 ± 2.22
IP112.61 ± 4.86b
IP + CHE34.07 ± 2.77d
IR + PMA165.47 ± 27.25b
Table 4 Changes in PKC phosphorylation activity during hypoxia in control and preconditioned hepatocytes (n = 6, mean ± SD)
GroupPhosphorylation activityof PKC (fmol/mg/min)
C32.67 ± 5.11
HR42.63 ± 4.73
HP109.42 ± 16.09b
HR + PMA152.47 ± 19.59b
HP + CHE65.28 ± 5.36d