Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma

Table 1 Clinicopathologic information of patients used in TMA

Group	HBV			Sex		Age	Diameter	Grade			Cirrhosis
	Total	Positive	Negative	Man	Female	mean ± SD (year)	mean ± SD (cm)	II	III	IV	Yes	No
HCC	181	171	10	158	23	49.3 ± 10.6	7.2 ± 3.5	28	141	12	166	15
Normal	5	0	5	2	3	42.4 ± 9.6	9.3 ± 5.8				0	5

Table 2 Expressions of HBx, p65, IκB-α and ubiquitin in HCC and corresponding liver tissues

Group	HBx			p65			IκB-α			Ubiquitin
	Total	Positive	%	Total	Positive	%	Total	Positive	%	Total	Positive	%
HCC	169	81	47.9	170	77	45.3	170	124	72.9	166	98	59.0
Control	170	102	60.0	170	35	20.6	171	116	67.0	168	15	8.9
Statistics		u = 2.24a			u = 4.85b			u = 1.19			u = 9.68b

^aP < 0.05,

^bP < 0.01.

Table 3 Relativity analysis between HBx, IκB-α, p65 and ubiquitin in HCC and corresponding liver tissues

		HBx		P65		Ubiquitin
		Negative	Positive	Negative	Positive	Negative	Positive
HBx	Negative			58(52)	30(16)	39(57)	46(8)
	Positive			33(83)	47(19)	28(95)	52(7)
Statistics				χ2 = 10.26b(0.60)		χ2 = 2.02(1.44)
IκB-α	Negative	29(21)	17(34)	36(46)	9(9)	26(50)	17(4)
	Positive	59(47)	63(68)	56(89)	68(26)	42(103)	80(11)
Statistics		χ2 = 2.28(0.11)		χ2 = 16.86b(1.02)		χ2 = 8.90b(0.04)

^bP < 0.01, vs Corresponding liver tissue.