Monocyte chemotactic protein-1 and soluble adhesion molecules as possible prognostic markers of the efficacy of antiviral treatment in chronic hepatitis C

Table 1 Levels of MCP-1, sICAM-1, sP-selectin, IL-6 and IL-10 in patients with chronic hepatitis C during IFN + RBV therapy in responders (R) and non-responders (NR)

		0-wk	16-wk	32-wk	48-wk	Control
sICAM-1 (pg/mL)	NR	434 ± 104ab	372 ± 111ab	404 ± 87b	389 ± 77b	230 ± 29
	R	527 ± 109ab	433 ± 87ab	353 ± 98b	363 ± 99
sP-selectin (pg/mL)	NR	240 ± 101ab	137 ± 47	145 ± 33	147 ± 41	144 ± 75
	R	144 ± 57a	131 ± 68	131 ± 58	23 ± 47
MCP-1 (pg/mL)	NR	290 ± 91	365 ± 124ab	315 ± 61	325 ± 50a	268 ± 109
	R	281 ± 84	285 ± 55a	335 ± 32b	286 ± 59a
IL10 (pg/mL)	NR	0.45 ± 0.46a	0.81 ± 0.54	0.77 ± 0.68	0.9 ± 0.63	0.62 ± 0.83
	R	0.88 ± 0.78a	0.89 ± 0.74	0.69 ± 0.73	1.01 ± 0.77
IL6 (pg/mL)	NR	0.65 ± 0.61ab	2.21 ± 0.94ab	1.07 ± 1.68b	1.56 ± 1.32b	0.22 ± 0.49
	R	0.16 ± 0.37ab	0.76 ± 0.69ab	0.77 ± 0.55b	1.05 ± 1.21b
ALT (IU/mL)	NR	82 ± 40	26 ± 17	23 ± 10	61 ± 91	32 ± 6
	R	60 ± 30	21 ± 6	24 ± 6	22 ± 6
Prothrombin index (%)	NR	96 ± 23	97 ± 6	98 ± 11	99 ± 10	98 ± 6
	R	5 ± 7	90 ± 10	83 ± 13	90 ± 7
Blood platelet (G/L)	NR	196 ± 21	189 ± 45	190 ± 52	179 ± 51	203 ± 45
	R	196 ± 21	189 ± 45	190 ± 52	17 ± 51

a-statistically significant differences between responders (R) and non-reponders (NR), Student’s t test,

^aP < 0.05, b-statistically signifi-cant differences compared to healthy, Student’s t test,

^bP < 0.01.

Table 2 Correlation of adhesion molecules, cytokines and MCP-1 levels with liver histopathology in responders (R) and non-responders (NR)

		Grading (inflammation)
		Periportal		Intralobular		Staging (fibrosis)
		R	NR	R	NR	R	NR
sICAM-1	r	N	0.36	0.38	0.56	N	0.32
	P	N	< 0.05	< 0.05	< 0.01	N	< 0.05
MCP-1	r	0.35	N	N	N	N	N
	P	< 0.05	N	N	N	N	N
IL-6	r	N	N	0.53	N	N	0.38
	P	N	N	< 0.01	N	N	< 0.05
IL-10	r	N	N	N	N	N	N
	P	N	N	N	N	N	N
sP-selectin	r	N	N	N	N	N	N
	P	N	N	N	N	N	N

r -statistical correlation, Spearman test, P < 0.05 statistical significant.