Effect of interleukin-10 and platelet-derived growth factor on expressions of matrix metalloproteinases-2 and tissue inhibitor of metalloproteinases-1 in rat fibrotic liver and cultured hepatic stellate cells

Table 1 Comparison of MMP-2 and TIMP-1 immunoreactivities between control, model and treatment groups

Group	MMP-2					TIMP-1
	n	-	+	++	Ridit value	-	+	++	Ridit value
Control	21	19	2	0	0.312	16	5	0	0.277b
Model	25	4	13	8	0.712d	2	14	9	0.684d
Treatment	28	17	10	1	0.451e	8	18	2	0.503g

^bP < 0.01 vs treatment group; ^cP < 0.05;

^dP < 0.01 vs control group;

^eP > 0.05 vs control group;

^gP < 0.05 vs model group.

Table 2 Comparison of MMP-2 and TIMP-1 immunoreactivities measured at different time points in model group

Wk	n	MMP-2				TIMP-1
		-	+	++	Ridit value	-	+	++	Ridit value
5	8	1	7	0	0.378	1	6	1	0.36ab
7	8	2	5	1	0.388	1	5	2	0.418e
9	9	1	1	7	0.709	0	2	7	0.698c

^bP < 0.01 vs wk 7 and 9;

^aP < 0.05 vs wk 9;

^cP < 0.05 vs wk 7;

^eP > 0.05 vs wk 5.