Inhibitory effect of Huangqi Zhechong decoction on liver fibrosis in rat

Table 1 Level of serum ALT, AST and liver Hyp

Group	n	ALT (U/L)	AST (U/L)	Liver Hyp (μg/mgprot)
Control	12	86.0 ± 17.7	329 ± 40	10.02 ± 1.05
Model	11	1 954 ± 576d	2735 ± 786d	26.47 ± 11.24d
High-dose group	9	989 ± 576ad	1 584 ± 988c	15.01 ± 7.59b
Medium-dose group	10	759 ± 380bc	1259 ± 829a	9.89 ± 3.74b
Low-dose group	10	1 003 ± 530ad	1 650 ± 928c	10.06 ± 2.58b

^aP < 0.05,

^bP < 0.01 vs model group;

^cP < 0.05,

^dP < 0.01 vs control group.

Table 2 Serum levels of HA, LN, PIIIP and type IV collagen

Group	n	PIIIP (ng/mL)	Type IV collagen (ng/mL)	LN (ng/mL)	HA (ng/mL)
Control	12	0.34 ± 0.67	18.47 ± 3.43	10.07 ± 1.74	17.96 ± 5.86
Model	11	3.26 ± 0.69d	77.68 ± 20.23d	31.62 ± 5.84d	42.74 ± 7.04d
High-dose group	9	2.01 ± 0.40bd	39.14 ± 4.97 bd	16.32 ± 2.73bd	21.71 ± 5.69b
Medium-dose group	10	1.47 ± 0.46bd	25.64 ± 4.68b	14.87 ± 1.45 bd	20.68 ± 5.85b
Low-dose group	10	1.84 ± 0.27bd	29.09 ± 2.78b	17.02 ± 2.74 bd	24.18 ± 7.89b

^aP < 0.05,

^bP < 0.01 vs model group; ^cP < 0.05,

^dP < 0.01 vs control group.

Table 3 Pathological observation of liver condition

Group	n	Liver condition					U
		0	I	II	III	IV
Model	11	0	0	0	3	8
High-dose group	9	0	2	3	3	1	2.98a
Medium-dose group	10	0	4	4	2	0	4.01b
Low-dose group	10	0	2	4	3	1	3.75b

^aP < 0.05,

^bP < 0.01 vs model group; The value of U represents the Ridit value of the two groups, U>1.96 means P < 0.05, U>2.58 means P < 0.01.