Clinicopathologic analysis of esophageal and cardiac cancers and survey of molecular expression on tissue arrays in Chaoshan littoral of China

Table 1 Sex ratio, average age of morbidity for EC and CC in Chaoshan littoral region (mean ± SD)

	n	Sex ( male:female)	Age(yr)	F	P
EC	9 635	7 228:2 407(3.0:1)	54.61 ± 10.73	103.24	< 0.001
CC	4 167	3 442:725(4.75:1)	58.14 ± 9.45

EC:CC = 2.31:1.

Table 2 Pathology for EC and CC in Chaoshan littoral region (%)

	Site			Gross type				Histological type
	U	M	L	UT	MT	ST	FT	SCA	ACA	UCA	O
EC	12.7	72.0	15.3	41.5	39.6	9.6	9.4	96.4	2.7	0.6	0.3
CC								4.4	94.5	0.9	0.2

Site (EC, n = 6 384); Gross type (EC, n = 1 193); Histological type (EC, n = 7 272; CC, n = 3 086); U: Upper third; M: Middle third; L: Lower third; UT: Ulcerative type; MT: Medullary type; ST: Scirrhous type; FT: Fungating type; SCA: Squamous cell carcinoma; ACA: Adenocarcinoma; UCA: Undifferentiated carcinoma; O: others.

Table 3 Expression of Erk1/Erk2 in esophageal squamous carcinoma tissue and para-cancerous tissue (%, mean ± SD)

	Normal esophagealsquamous cell (n = 5)	Para-canceroustissue (n = 5)	Grade I (n = 19)	Grade II (n = 34)	Grade III (n = 9)	F	P
Activated ERK1/ERK2	5.10 ± 1.44	76.80 ± 0.14	76.80 ± 0.09	75.80 ± 0.09	69.30 ± 0.14	2.60	0.04

There was marked difference between normal esophageal epithelium and cancer tissues or para-cancerous tissue. But there was no marked difference among para–cancerous tissues and esophageal squamous carcinoma tissues (F = 1.463, P = 0.236).