Curative effects of interferon-α and HLA-DRB1 -DQA1 and -DQB1 alleles in chronic viral hepatitis B

Table 1 Comparison of frequency of HLA-DRB1 allele among non-responders and partial and complete responders

Allele	Partial and complete responders (n = 34)	Non-responders (n = 26)	χ2
DRB1*10(+)	1	0	0.778
DRB1*11(+)	9	3	2.053
DRB1*4(+)a	1	6	2.053
DRB1*12(+)	9	7	0.002
DRB1*8(+)	4	5	0.644
DRB1*9(+)	15	11	0.020
DRB1*14(+)	4	4	0.167
DRB1*15(+)	8	10	1.564
DRB1*17(+)	1	2	0.700
DRB1*16(+)	3	0	2.415
DRB1*7(+)	4	0	3.277

^aP < 0.025.

Table 2 Comparison of HLA-DQA1 allele frequencies among non-responders and partial and complete responders

Allele	Partial and complete responders (n = 32)	Non-responders (n = 28)	χ2
DQA1*0105(+)	1	0	0.890
DQA1*0505(+)a	12	3	5.714
DQA1*0303(+)b	0	6	7.619
DQA1*0601(+)	10	7	0.287
DQA1*0103(+)	9	7	0.075
DQA1*0302(+)	15	12	0.097
DQA1*0104(+)	4	4	0.041
DQA1*0102(+)	4	6	0.857
DQA1*0301(+)	1	4	2.435

^aP < 0.025.

^bP < 0.01.

Table 3 comparison of frequencies of HLA-DQB1 allele among non-responders and partial and complete responders

Allele	Partial and complete responders (n = 32)	Non-responders (n = 28)	χ2
DQB1*0502(+)	6	1	3.338
DQB1*0301(+)a	20	7	8.485
DQB1*0401(+)	1	3	1.382
DQB1*0303(+)	15	12	0.097
DQB1*0503(+)	3	4	0.431
DQB1*0601(+)	6	9	1.429

^aP < 0.005.