Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity

Table 1 Liver function tests during the 10-day observation period

		Day 2	Day 5	Day 10
Total Bilirubin (mg/dL)	A	0.53 ± 0.05	0.33 ± 0.05	0.35 ± 0.10
	B	0.60 ± 0.10	0.46 ± 0.05	0.37 ± 0.14
	C	0.86 ± 0.10	0.76 ± 0.10	1
	D	0.86 ± 0.15	0.66 ± 0.15	0.20 ± 0.10
SGPT (IU/L)	A	273 ± 76.2	67.5 ± 32.1	29.2 ± 11
	B	400.3 ± 155	61.6 ± 27.7	54.8 ± 25.0
	C	710 ± 29.3	90.3 ± 23.1	1
	D	507.3 ± 91.2	66 ± 22.7	56.3 ± 14.9
SGOT (IU/L)	A	380.6 ± 63.4	68.3 ± 24.1	84 ± 13.3
	B	779.3 ± 235.2	287.6 ± 114	76.8 ± 30.9
	C	1088.3 ± 131.7	610.6 ± 148.6	1
	D	836.6 ± 171.2	250.6 ± 139.6	112 ± 63.2
Alkaline Phosphatase (IU/L)	A	469.3 ± 157.5	427.6 ± 129.5	343.1 ± 180.5
	B	88.6 ± 50	58.6 ± 39	564.3 ± 142.7
	C	123.6 ± 50.5	116.3 ± 37.4	1
	D	104 ± 31.1	129.3 ± 41.7	792.3 ± 246.5

All differences between final and baseline values were statistically significant. ¹All animals died before d 10. (Normal Values: Total Bilirubin: 0.18 ± 0.07 mg/dL, SGPT: 44.1 ± 24.8 IU/L, SGOT: 53.4 ± 23.6 IU/L, Alk. Phosphatase: 86.8 ± 49.6 IU/L -Baseline Value: Total Bilirubin: 0.6 ± 0.09 mg/dL, SGPT: 616.1 ± 117.5 IU/L, SGOT: 1296.7 ± 381.2 IU/L, Alk. Phosphatase: 91.4 ± 63 IU/L).