Domperidone improves gallbladder emptying function in patients with irritable bowel syndrome

Table 1 Characteristics of patients and controls studied

Characteristics	Patients (n = 20)	Controls (n = 18)
Mean age (a)	33.15 ± 2.16	32.85 ± 2.25
(Range)	(18-56)	(22-54)
Males/Females	11/9	9/9
Mean weight (kg)	59.45 ± 1.47	57.77 ± 1.26
(Range)	(46.5-70.4)	(47.0-67.5)
Mean height (cm)	165.50 ± 1.13	166.80 ± 1.21
(Range)	(155.5 ± 178.2)	(154.6 ± 179.0)
Mean body index (kg/m2)	22.24 ± 1.21	22.07 ± 1.26
mass (Range)	(16.24 ± 26.21)	(17.69 ± 24.82)

Table 2 Comparison of Gallbladder ejection fraction after oral domperidone in irritable bowel syndrome patients and controls

Drug	Subjects	15 min	30 min	45 min	60 min
No drug	patients	25.93 ± 2.06b	44.54 ± 2.49b	54.16 ± 1.87b	65.11 ± 2.10b
	controls	32.63 ± 2.34	53.79 ± 2.32	70.32 ± 1.85	80.13 ± 1.81
Dom 1	patients	34.26 ± 1.42a	58.37 ± 1.77b	71.22 ± 1.50a	79.66 ± 1.09e
	controls	30.63 ± 2.40	50.68 ± 3.05	67.72 ± 1.95	77.74 ± 1.09
Dom 2	patients	41.10 ± 1.55e	64.98 ± 1.03b	74.81 ± 1.45a	82.74 ± 1.32b
	controls	29.63 ± 1.38	49.34 ± 2.24	63.26 ± 1.69	70.95 ± 1.45

^eP > 0.05,

^aP < 0.05,

^bP < 0.01, vs controls. Dom: Domperidone.

Table 3 Comparison of Gallbladder ejection fraction after oral domperidone in irritable bowel syndrome patients with different subtypes

Drug Type	15 min	30 min	45 min	60 min
Nil Hypermotility	26.68 ± 2.83	47.61 ± 2.62	58.18 ± 2.31	69.80 ± 1.87
Type Segmental contraction	29.20 ± 2.68a	40.98 ± 2.39b	49.49 ± 2.51c	60.96 ± 1.92c
Others	24.42 ± 1.82b	24.42 ± 1.82b	48.43 ± 1.64	55.43 ± 1.72b
Dom 1 Hypermotility	33.34 ± 2.15	62.04 ± 2.11	73.99 ± 1.76	82.27 ± 1.86
Segmental contraction	35.11 ± 1.66	57.90 ± 1.63	69.34 ± 1.87	77.45 ± 1.59b
Others	31.34 ± 2.63b	55.89 ± 2.51	68.29 ± 2.03	77.64 ± 1.83
Dom 2 Hypermotility	40.09 ± 2.22	66.02 ± 1.91	79.69 ± 1.70	84.78 ± 1.70
Segmental contraction	38.87 ± 1.81a	62.93 ± 1.65b	74.62 ± 1.64b	81.38 ± 1.78a
Others	43.91 ± 2.06	69.71 ± 1.81b	77.91 ± 1.55b	83.01 ± 1.58

^aP > 0.05,

^bP < 0.05,

^cP < 0.01. Dom: Domperidone.