Activity of boanmycin against colorectal cancer

Table 3 Inhibitory effect of BAM, MMC and 5-FU on the growth of CT-26 tumor at the cecum and s.c site in mice*

Exp.	Drug	Dose** (mg/kg)	No. of mice	s.c. tumor		Cecal tumor
				Tumor weight (g) x-± s	Inhibitory rate (%)	Tumor weight (g) x-± s	Inhibitory rate (%)
I	Control		9	0.854 ± 0.151		0.557 ± 0.112
	BAM	10	9	0.101 ± 0.054	88b	0.005 ± 0.010	99b
	MMC	1	8	0.311 ± 0.105	64	0.159 ± 0.043	71
	5-FU	27	8	0.459 ± 0.118	46	0.310 ± 0.148	44
II	Control		6	0.900 ± 0.396		0.740 ± 0.446
	BAM	10	6	0.105 ± 0.088	88b	0.011 ± 0.019	99b
	MMC	1	5	0.674 ± 0.270	25	0.159 ± 0.510	78
	5-FU	27	6	0.657 ± 0.322	27	0.434 ± 0.255	41

*Treatment was started on next day after tumor cell injection, im., qod., with a total of 10 injections.

^**Drugs were administered at equitoxic doses (1/9 LD50).

^bP < 0.01, vs any other group.