Changes of IL-6 and relevant cytokines in patients with hepatocellular carcinoma and their clinical significance

doi:10.3748/wjg.v6.iSuppl3.53

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Sep 15, 2000 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 53-53
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.53

Changes of IL-6 and relevant cytokines in patients with hepatocellular carcinoma and their clinical significance

Cai-Yan Zhao, Yue-Lin Li, Su-Xia Liu, Zhong-Jun Feng

Cai-Yan Zhao, Yue-Lin Li, Su-Xia Liu, Zhong-Jun Feng, Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Cai-Yan Zhao, Third Hospital of Medical University, 16 Weiming Road, Shijiazhuang 050051, Hebei Province, China. Wangyans@sj-user.he.cninfo.net

Telephone: 311-7027951-2190(O), 7760298(H)

Received: May 30, 2000
Revised: June 16, 2000
Accepted: July 10, 2000
Published online: September 15, 2000

Abstract

AIM: To study the changes of interleukin(IL)-6, IL-2, sIL-2R and TNF in patients with hepatocellular carcinoma（HCC）and their clinical significance.

METHODS: IL-6, IL-2, sIL-2R and TNF were detected by avidin-biotin-system enzyme linked immunosorbent assay (ELISA), double-sandwich ELISA respectively in 60 patients with HCC and 36 patients with liver cirrhosis (LC) and 66 healthy persons.

RESULTS: The levels of IL-6, sIL-2R and TNF increased, but IL-2 level was lower in patients with HCC than that in normal controls (NC) (t test, t = 8.21, 4.71, 3.87, 2.13, P < 0.01 or 0.05). IL-6 level in HCC was 10 fold higher than NC, and also much higher than LC. IL-6 level was higher in later stage than that in earlier stage. There was a positive correlation between IL-6 and sIL-2R, TNF, while no positive correlation was found between IL-2 and IL-6, sIL-2R in HCC.

CONCLUSION: The remarkably higher level of IL-6 is helpful for the early diagnosis of HCC.

Key Words: Liver neoplasms/immunology, Interleukin-6/analysis, Interleukin-2/analysis, Tumor necrosis factor/analysis, Cytokines, Liver cirrhosis

Citation: Zhao CY, Li YL, Liu SX, Feng ZJ. Changes of IL-6 and relevant cytokines in patients with hepatocellular carcinoma and their clinical significance. World J Gastroenterol 2000; 6(Suppl3): 53-53
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/53.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.53

Footnotes

E- Editor: Zhang FF