Protective effect of Irsogladine on monochloramine induced gastric mucosal lesions in rats: a comparative study with rebamipide

Figure 4 Effects of irsogladine and rebamipide on changes in transmucosal PD in response to NH₄OH in rat stomachs under ischemic conditions. The stomach mounted on a ex-vivo chamber was subjected to ische mia by bleeding from the carotid artery (1 mL/100 g body wt), and then e xposed to NH₄OH (120 mM; 1 mL) for 1h thereafter. Irsogladine (3 mg/kg) or rebamipide (100 mg/kg) was applied to the chamber 20 min before the onset of ischemia and NH₄OH treatment. Indomethacin (5 mg/kg, sc) or L-NAME (10 mg/kg, iv) was given 30 or 10 min before the above agents. Data are presented as the mean ± SE of values determined every 5 min from 5-6 rats. Statistically significant difference at P < 0.05; *from control; #from vehicle.