Protective effect of Irsogladine on monochloramine induced gastric mucosal lesions in rats: a comparative study with rebamipide

Figure 3 Effects of irsogladine and rebamipide on ch anges in transmucosal PD in response to NH₂Cl in anesthetized rat stomachs. Th e stomach was mounted on an ex-vivo chamber, and NH₂Cl (20 mM; 1 mL) was applied topically to the stomach for 10min. Irsogladine (3 mg/kg) or rebamipide (100 mg/kg) was applied to the chamber for 30 min, starting 20 min before exposure to NH₂Cl. Data are presented as the mean ± SE of value sdetermined every 5 min from 5-7 rats. ^aStatistically significant differen ce from control, P < 0.05.