Characterization of six tumor suppressor genes and microsatellite instability in hepatocellular carcinoma in southern African blacks

doi:10.3748/wjg.v5.i6.470

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Dec 15, 1999 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 15, 1999; 5(6): 470-476
Published online Dec 15, 1999. doi: 10.3748/wjg.v5.i6.470

Table 2 LOH, SSCP and sequence analysis

Subject number	VNTRs										p53 codon 249		HBV status
	p53	WT1	RB1		BRCA2		BRCA1		E-cadherin		p53 codon 249
	(ALU)	(AC)	D13S137 (GT)₂₂	RB1.20 [CTTT(T)]_n	D13S120 (AC)₇₃	D13S127 (AC)₃₅	D17S855 (AC)	D17S846 (GGAA)₂₅	D16S301 (AC)	D16S260 (AC)	T	NT
1	NI	NI	-	-	-	NI	-	-	-	NI	-/-	-/-	HBsAg+; HBeAg-
2	-	-	-	-	-	NI	-	-	-	NI	-/-	-/-	HBsAg+
3	-	-	-	-	-	-	-	-	NI	-	+/-	-/-	HBsAg+; HBeAg-
4	-	-	-	NI	-	-	?	NI	-	-	-/-	-/-	anti-HBc+; anti-HBs+
6	-	?	?	?	-	NI	?	-	?	-	+/-	-/-	HBsAg+; HBeAg-
7	?	?	?	?	-	-	?	?	-	-	-/-	-/-	anti-HBs+; anti-HBc+
8	↑	△	NI	+	↓	↓	△	△	↑	-	+/-	-/-	anti-HBs+; anti-HBc+
14	-	NI	?	NI	-	+	-	?	?	NI	-/-	-/-	anti-HBs+; anti-HBc+
16	?	?	△	?	+	+	?	?	△	↑	-/-	-/-	HBsAg+
18	↑	+	?	?	↑	-	?	?	?	↑	-/-	-/-	HBsAg+; HBeAg-
24	NI	-	NI	-	-	-	-	-	NI	-	-/-	+/-	anti-HBs+; anti-HBc+
39	-	NI	-	?	-	-	-	NI	?	-	-/-	-/-	HBsAg+; HBeAg-
40	NI	-	?	-	-	NI	-	-	?	-	-/-	-/-	anti-HBs+; anti-HBc+
48	NI	-	-	-	-	-	-	-	?	?	-/-	-/-	?
50	NI	-	-	NI	-	-	-	NI	-	NI	-/-	-/-	?
51	NI	-	?	NI	-	NI	-	-	-	-	-/-	-/-	?
52	NI	-	NI	-	-	NI	-	-	-	-	+/-	-/-	?
53	-	-	-	-	-	-	-	-	NI	-	-/-	-/-	?
54	-	?	-	-	-	-	-	-	-	NI	-/-	-/-	?
56	NI	-	-	NI	-	-	-	NI	NI	NI	-/-	-/-	?

Note: LOH: loss of heterozygosity; -: HBV status-negative for particular antigen/antibody, mutation studies-mutation absent; LOH studies: no LOH; →p53 codon 249 mutation analysis: G→T transversion absent; +: HBV status-positive for particular antigen/ antibody, mutation studies-mutation present, →LOH studies: LOH, →p53 codon 249 mutation analysis: G→T transversion present; ?: results not obtained because of unsuccessful PCR or HBV status unknown; △: a change in repeat number between tumor (T) and non-tumorous liver (NT) in both chromosomes; ↑/↓: an increase/decrease in repeat number between tumor (T) and non-tumorou s liver (NT) in one chromosome; NI: not informative; VNTRs: Variable number of tandem repeat sequences; HBV: Hepatitis B virus; WT1: Wilm’s tumor gene; RB1: Retinoblastoma gene; BRCA1: Breast cancer susceptibility gene 1; BRCA2: Breast cancer susceptibility gene 2; HBsAg: hepatitis B virus S antigen; HBeAg: hepatitis B virus E antigen; anti-HBs: antibody to hepatitis B virus S antigen; anti-HBc: antibody to hepatitis B virus C antigen

Citation: Martins C, Kedda M, Kew M. Characterization of six tumor suppressor genes and microsatellite instability in hepatocellular carcinoma in southern African blacks. World J Gastroenterol 1999; 5(6): 470-476
URL: https://www.wjgnet.com/1007-9327/full/v5/i6/470.htm
DOI: https://dx.doi.org/10.3748/wjg.v5.i6.470