Evaluation of the effect of three anticrobial therapieson eradication of Helicobacter pylori

Abstract

AIM: To evaluate the effect of three kinds of anti-Helicobacter pylori (Hp) therapies on eradication of Hp.

METHODS: One hundred and fifty-one patients with confirmed presence of Hp were enrolled into the study, and were randomly divided into three groups A, B and C. Group A took Denol 120 mg-tid, Amoxycillin 500 mg bid, Cimetidine 400 mg bid, and Metronidazole 200 mg tid; Group B Ranitidine 300 mg bid, Denol 120 mg tid, Furazolidonum 100 mg tid, Amox ycillin 500 mg bid; and group C Losec 20 mg qd, Amoxycillin 500 mg bid, Denol 120 mg tid, Famotidine 200 mg bid, respectively, for 2 wk. Endoscopy and ¹⁴C-UBT were repeatedly performed 4 wk after antimicrobial therapy ended.

RESULTS: The eradication rates of H.Pylori in Group A, B and C were 93.3% (36/39), 92.1% (35/38) and 95.0% (38/40), respectively, and there was no significant difference in the eradication rates between the three groups (P > 0.05). The ulcer healing rates in group A, B and C were 90.0% (9/10), 92.3% (12/13) and 91.0% (10/11), respectively, and there was no significant difference between the treatment groups, either. The incidence of drug-induced side-effect was similar among the three groups.

CONCLUSION: All the three anti-H.Pylori remedies are the treatment of choice in eradication of Hp.

Key Words: Helicobacter infections/drug therapy, Amoxici llin/therapeutic use, Cimetidine/therapeutic use, Organometalic compounds/therap eutic use, Omeprazole/therapeutic use