Abstracts Open Access
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 1998; 4(Suppl2): 141-141
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.141
Relation between p16 expression and biological behavior of gastric carcinoma
Lin Zhang, Hong-Mei Fu, Shu-Zhen Jin, Department of Pathology, Kunming Medical College, Kunming 650032, Yunnan Province, China
Cheng-Gang Zhou, General surgery of First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Lin Zhang, Department of Pathology, Kunming Medical College, Kunming 650032, Yunnan Province, China
Received: July 21, 1998
Revised: August 20, 1998
Accepted: September 11, 1998
Published online: October 15, 1998

Abstract

AIM: To discuss the relationship between p16 expression and biological behavior of gastric carcinoma.

METHODS: Immunohistochemical methods were used in this study to detect p16 expression of gastric carcinoma and normal gastric tissues.

RESULTS: The expression levels of P16 protein in normal gastric tissue and gastric carcinoma were separately 100.0% (12/12) and 39.2% (20/51). There was significant difference (P < 0.001). The positive rate of P16 protein expression was not related to the differentiation and the cancerous infiltration degree of gastric carcinoma (P > 0.05). In the cases with or without lymphnode metastasis, the positive rate of p16 protein was 25.8% (8/31) and 60.0% (12/20), there was significant difference (P < 0.00).

CONCLUSION: The defect expression of P16 protein was correlated with occurrence and lymphnode metastasis of gastric carcinoma. Determination of P16 Protein expression may be useful in diagnosis and predicting prognosis of gastric carcinoma.

Key Words: Stomach neoplasms, p16 gene, Lymphatic metastasis, Immunohistochemistry



Footnotes

E- Editor: Li RF

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