Study on the relationship between Helicobacter pylori infection and proliferative kinetics of gastric mucosa

doi:10.3748/wjg.v4.iSuppl2.118

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 4, Issue Suppl2

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (652)

All Articles published online

The chart showing PDF series, HTML series.

Item

Count

PDF

HTML

580

Sum=652

Oct 15, 1998 (publication date) through Apr 26, 2024

Times Cited of This Article

Times Cited (1)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Abstracts Open Access

World J Gastroenterol. Oct 15, 1998; 4(Suppl2): 118-118
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.118

Study on the relationship between Helicobacter pylori infection and proliferative kinetics of gastric mucosa

Yun-Hua Zhu, Ya-Ru Wang, Jing-Jun Sun, Chang-Le Zhu, Xu Wu, Bin Lu

Yun-Hua Zhu, Ya-Ru Wang, Jing-Jun Sun, Chang-Le Zhu, Xu Wu, Bin Lu, Department of Pathology, Jiangsu Province Hospital of Tranditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Yun-Hua Zhu, Department of Pathology, Jiangsu Province Hospital of Tranditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China

Received: July 5, 1998
Revised: August 16, 1998
Accepted: September 4, 1998
Published online: October 15, 1998

Abstract

AIM: To explore the relationship between Helicobacter pylori (Hp) and proliferative activities of gastric mucosa.

METHODS: The date from the 68 cases of chronic gastritis biopsy specimens. The Hp detected by histological methods (wathing- sterry, w.s. Silver-staining and 0.25% Fuchsin Basic staining and PCR techniques. The proliferating cell nuclear antigen (PCNA), C-erb-B2 and p53 gene protein expressions were analysed immunochemically (ABC method) Sliver-binding nucleolar regions (AgNOR) were counted.

RESULTS: The Hp positive were 30 cases and Hp negative were 38 cases. The I,II, III, IV degree positive expressions of PCNA were 5, 7, 4, 14 and 27, 11, 0, 0 in Hp positive and Hp negative respectively (P < 0.05). The AgNOR counts of the former significantly more than that of the later (3.44 ± 1. 20 and 1.08 ± 0.08, respectively) (P < 0.05). The C-erb-B2 expressions were negative in non-Hp infected mucosa, but the local positive expressions were found in 4 Hp infected mucosa. The p53 were negative in chronic gastritis whether Hp positive or negative.

CONCLUSION: The proliferative kinetics of Hp infected gastric mucosa increased, that may be one of the risk factors of gastric carcinogenesis

Key Words: Helicobacter infection, Helicobacter pylori, Gastric mucosa/pathology

Citation: Zhu YH, Wang YR, Sun JJ, Zhu CL, Wu X, Lu B. Study on the relationship between Helicobacter pylori infection and proliferative kinetics of gastric mucosa. World J Gastroenterol 1998; 4(Suppl2): 118-118
URL: https://www.wjgnet.com/1007-9327/full/v4/iSuppl2/118.htm
DOI: https://dx.doi.org/10.3748/wjg.v4.iSuppl2.118

Footnotes

E- Editor: Li RF