Clinical research on plasma motilin levels and cutaneous electrogastrogram in patients with functional dyspepsia

Abstract

AIM: To investigate the relationship between plasma motilin, cutaneous electrogastrogram (EGG) and functional dyspepsia, and to further investi gate the etiology of the disease.

METHODS: Samples from peripheral venous blood were collected 12 h after fasting and 30 min after the testmeal in the morning in 30 d peptic patients and 30 volunteers, respectively. EGG were recorded concurrently for every person. The students' t test was used to analyse the result.

RESULTS: The plasma motilin level in the dysmotility-like dyspe psia at fasting was significantly lower than that of the control (P < 0.01); both of the plasma motilin levels at fasting and postprandial state of the other three types of functional dyspepsia were significantly higher than those of the normal subjects (P < 0.01); The gastric electrical dysrrhythmia rates of all patients were significantly higher than those of the control whether at fasti ng state or postprandially (P < 0.005); The gastric electrical amplitude of the patients after the test meal was significantly lower than that of the control (P < 0.025 and P < 0.005).

CONCLUSION: The abnormality of the plasma motilin concentration and the gastric electrical activity leading to gastric hypomotility might be the essential pathophysiological mechanism of functional dyspepsia.

Key Words: Dyspepsia/Etiology, Dyspepsia/Classification, Motilin/Blood, Electrogastrogram