Brief Reports Open Access
Copyright ©The Author(s) 1997. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 1997; 3(3): 179-179
Published online Sep 15, 1997. doi: 10.3748/wjg.v3.i3.179
Effects of electro-acupuncture on 5-HT, NOS and the gastric mucosa of stress rats
Shun-Li Zhu, Guan-Sun Xu, Zhen-Jiu Wang, Quan-Zhu Chen, Jie Jiao, Institute of Acupuncture and Meridians, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Shun-Li Zhu, Institute of Acupuncture and Meridians, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China
Received: October 31, 1996
Revised: December 22, 1996
Accepted: January 30, 1997
Published online: September 15, 1997

Abstract

AIM: To study the effects of electro-acupuncture (EA) on 5-hydroxytryptophan (5-HT) levels, nitrous oxide (NOS) levels, nitric oxide (NO) levels, and the gastric mucosa in stress rats.

METHODS: The changes of 5-HT and NOS were measured in the gastric mucosa, and NO and 5-HT were measured in the serum by biochemical methods. The gastric mucosa was examined pathohistologically in the stress rats with gastric mucosa damage after EA. The changes before and after stress by EA were compared.

RESULTS: EA decreased the gastric mucosa damage index in the stress rats (2.71 ± 0.40 to 1.86 ± 0.69, P < 0.01). EA normalized NOS level in gastric mucosa to the control group. The changes before stress by EA was more obvious than that after stress. EA lowered the 5-HT levels in the gastric mucosa (μg/g wet weight, 6.91 ± 3.08 to 4.51 ± 1.62, P < 0.01). EA recovered the NO level in serum of the stress rats (μmol/L, 5.78 ± 1.49 to 7.91 ± 1.11, P < 0.05), and increased the levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in serum continuously.

CONCLUSION: EA stimulation normalizes the NOS and NO levels in the gastric mucosa of stress rats. EA also lowers the high 5-HT levels and induces NO release.

Key Words: Electroacupuncture; Serotonin/acu-moxibustion effects; Aminoacid oxidoreductases/acu-moxibustion effects; Gastric mucosa/Acu-moxibustion effects



Footnotes

Original title: China National Journal of New Gastroenterology (1995-1997) renamed World Journal of Gastroenterology (1998-)

S- Editor: Filipodia L- Editor: Jennifer E- Editor: Hu S

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