Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments

Figure 3 Evaluation of the target genes of tRNA-derived fragments 36 for the cell ferroptosis process in acute pancreatitis. A: Functional enrichment analysis for the target genes of tRNA-derived fragments 36; B: Hematoxylin and eosin staining results of lung and pancreatic tissues in the acute pancreatitis (AP) mouse model; C and D: The serum levels of lipase and amylase in the AP mouse model; E-G: The serum levels of the inflammatory factors interleukin-1β (E), interleukin-6 (F), and tumor necrosis factor-α (G); H: The expression of ferritin in the mouse pancreatic tissues with AP; I: The levels of malondialdehyde in mouse pancreatic tissues with AP; J: The ferric ion concentration in mouse pancreatic tissues with AP. a and b represent different expression levels, the same letter represents no significant difference between groups (P > 0.05), different letters represent significant difference between groups (P < 0.05). tRF-36: tRNA-derived fragments 36; IL: Interleukin; TNF: Tumor necrosis factor; NC: Normal control; mTOR: Mechanistic target of rapamycin; HIF-1: Hypoxia-inducible factor 1; FDR: False discovery rate; PI3K-AKT: Phosphatidylinositol-4,5-bisphosphate 3-kinase-protein kinase B; ErbB: Erythroblastic oncogene B; AP: Acute pancreatitis; MDA: Malondialdehyde; AMS: Amylase.