Effectiveness, safety, and drug sustainability of biologics in elderly patients with inflammatory bowel disease: A retrospective study
Gustavo Drügg Hahn, Petra Anna Golovics, Panu Wetwittayakhlang, Abdulrahman Qatomah, Anna Wang, Levon Boodaghians, Maryam Al Ali, Gary Wild, Waqqas Afif, Alain Bitton, Peter Laszlo Lakatos, Talat Bessissow, Division of Gastroenterology, IBD Center, McGill University Health Center, Montreal H3G 1A4, Quebec, Canada
Gustavo Drügg Hahn, School of Medicine, Graduate Course Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90000-000, Brazil
Jean-Frédéric LeBlanc, Division of Gastroenterology, McGill University Health Centre, Montreal H3G 1A4, Quebec, Canada
Petra Anna Golovics, Department of Gastroenterology, Hungarian Defense Forces, Medical Centre, Budapest 1134, Hungary
Panu Wetwittayakhlang, Unit of Gastroenterology and Hepatology, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand
Jeremy Liu Chen Kiow, Department of Gastroenterology, Centre Hospitalier de l’Université de Montréal, Montreal H2X 3E4, Quebec, Canada
Author contributions: Hahn GD and Bessissow T are guarantors of the manuscript; LeBlanc JF and Bessissow T designed the study; LeBlanc JF, Qatomah A, Wang A, Boodaghians L, Liu Chen Kiow J and Al Ali M performed the data collection; Drügg Hahn G, LeBlanc JF, Golovics PA, Wetwittayakhlang P, Lakatos PL and Bessissow T performed the data interpretation; Lakatos PL performed the statistical analysis; Drügg Hahn G wrote the initial draft of the manuscript, and Golovics PA, Wetwittayakhlang P, Wild G, Afif W, Bitton A, Lakatos PL and Bessissow T were involved in the critical revision of the manuscript; and all the authors reviewed and approved the final manuscript.
Institutional review board statement: The study was approved by the Research Ethics Board of McGill University Health care center, Montreal, Quebec, Canada, under protocol No. 2019-5209. Individual patient-level data were de-identified to maintain confidentiality in all steps of study analysis. This study was conducted in compliance with regulations stated in the 1975 Declaration of Helsinki.
Informed consent statement: Informed consent was obtained from each patient included in the study.
Conflict-of-interest statement: Hahn GD, Qatomah A, Wang A, Boodaghians L, Liu Chen Kiow J, Al Ali M, and Wild G declared no conflict of interest; LeBlanc JF has been a speaker or advisory board member for Janssen and Takeda; Golovics PA has been a speaker for AbbVie, Takeda, Fresenius, Ferring; Wetwittayakhlang P has been a speaker and/or advisory board member: Takeda, Pfizer, Janssen, Ferring, A. Menerini, and MSD; Afif W has been a speaker for Janssen, Prometheus, Dynacare, Takeda, AbbVie Theradiag; Bitton A has been a member of Advisory Boards - Abbvie, Pfizer, Takeda, Janssen, Merck; Speaker’s bureau - Abbvie, Janssen, Takeda, Pfizer; Lakatos PL has been a speaker and/or advisory board member for AbbVie, Arena, Falk Pharma GmbH, Ferring, Genetech, Janssen, Kyowa Hakko Kirin Pharma, Mitsubishi Tanabe Pharma Corporation, MSD, Pfizer, Roche, Shire, Takeda and Tillots, and has received unrestricted research grants from AbbVie, MSD and Pfizer; Bessissow T has been a speaker or advisory board member for Takeda, Janssen, Abbvie, Merck, Pfizer, Pendopharm, Ferring, Shire, Sandoz, BMS, Roche, Fresenius Kabi, Viatris.
Data sharing statement: The main data are given in this article. The data are available from the corresponding author upon request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peter Laszlo Lakatos, AGAF, DSc, FEBG, MD, PhD, Chief Physician, Professor, Division of Gastroenterology, IBD Center, McGill University Health Center, 1650 Ave. Cedar, D7.211, Montreal H3G 1A4, Quebec, Canada. email@example.com
Received: January 28, 2022
Peer-review started: January 28, 2022
First decision: March 11, 2022
Revised: March 17, 2022
Accepted: August 14, 2022
Article in press: August 14, 2022
Published online: September 7, 2022