Observational Study
Copyright ©The Author(s) 2021.
World J Gastroenterol. Nov 28, 2021; 27(44): 7705-7715
Published online Nov 28, 2021. doi: 10.3748/wjg.v27.i44.7705
Figure 3
Figure 3 Histopathochemistry and functional results of homozygous interleukin 10 receptor alpha subunit mutation. A: Histological findings in a colonic specimen obtained during colonoscopy showing oval-shaped intramural abscesses; B: Higher magnification of inset A; C: Determination of TNF-α levels in the supernatant of cultured PBMCs from patient D after stimulation with PBS, LPS, or LPS + IL-10 in vitro; D: Western blot results of PBMCs isolated from patient D after stimulation with LPS or IL-10. Phosphorylation of STAT3 at Tyr705 and Ser727 and total STAT3 protein were detected (n = 3). aP < 0.05, bP < 0.01, and cP < 0.001 were considered as statistically different.