Minireviews Open Access
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2019; 25(21): 2591-2602
Published online Jun 7, 2019. doi: 10.3748/wjg.v25.i21.2591
Liver transplantation for hepatocellular carcinoma: Where do we stand?
Francesco Santopaolo, Ilaria Lenci, Martina Milana, Leonardo Baiocchi, Hepatology Unit, Department of Medicine, Policlinico Universitario Tor Vergata, Rome 00133, Italy
Tommaso Maria Manzia, Transplant Surgery Unit, Department of Surgery, Policlinico Universitario Tor Vergata, Rome 00133, Italy
ORCID number: Francesco Santopaolo (0000-0002-1773-1171); Ilaria Lenci (0000-0001-5704-9890); Martina Milana (0000-0003-2027-0481); Tommaso Maria Manzia (0000-0002-4636-3478); Leonardo Baiocchi (0000-0003-3672-4505).
Author contributions: Santopaolo F and Baiocchi L wrote the paper; Lenci I, Milana M, and Manzia TM collaborate with tables, retrieved references; Baiocchi L suggested the paper, elaborate table; Lenci I, Milana M, Manzia TM, and Baiocchi L revised the paper.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Leonardo Baiocchi, MD, PhD, Assistant Professor, Hepatology Unit, Department of Medicine, Policlinico Universitario Tor Vergata, Viale Oxford 81, Rome 00133, Italy.
Telephone: +39-620902626
Received: February 28, 2019
Peer-review started: March 1, 2019
First decision: March 5, 2019
Revised: April 9, 2019
Accepted: April 29, 2019
Article in press: April 29, 2019
Published online: June 7, 2019
Processing time: 98 Days and 16.6 Hours


Hepatocellular carcinoma represents an important cause of morbidity and mortality worldwide. It is the sixth most common cancer and the fourth leading cause of cancer death. Liver transplantation is a key tool for the treatment of this disease in human therefore hepatocellular carcinoma is increasing as primary indication for grafting. Although liver transplantation represents an outstanding therapy for hepatocellular carcinoma, due to organ shortage, the careful selection and management of patients who may have a major survival benefit after grafting remains a fundamental question. In fact, only some stages of the disease seem amenable of this therapeutic option, stimulating the debate on the appropriate criteria to select candidates. In this review we focused on current criteria to select patients with hepatocellular carcinoma for liver transplantation as well as on the strategies (bridging) to avoid disease progression and exclusion from grafting during the stay on wait list. The treatments used to bring patients within acceptable criteria (down-staging), when their tumor burden exceeds the standard criteria for transplant, are also reported. Finally, we examined tumor reappearance following liver transplantation. This occurrence is estimated to be approximately 8%-20% in different studies. The possible approaches to prevent this outcome after transplant are reported with the corresponding results.

Key Words: Hepatocellular carcinoma, Liver transplantation, Bridging, Down-staging, Milan Criteria

Core tip: Liver transplantation is an important tool for the treatment of hepatocellular carcinoma in human. In this review we focused on the main debated issues in this field including: (1) Criteria for candidate selection; (2) Bridging therapy to transplant; and (3) Down-staging of patients exceeding transplant criteria. Tumor recurrence rate in the graft and strategies to prevent this occurrence, are also discussed.


Hepatocellular carcinoma (HCC) represents the most prevalent primary liver tumor in the world and is consequently a relevant health issue. With 841080 diagnosed cases and 781631 deaths in 2018, and an age-adjusted worldwide incidence of 9.3 cases per 100000 people/year, HCC is the sixth most frequent tumor and the fourth leading cause of cancer death[1]. HCC occurs mostly in the setting of chronic liver disease and cirrhosis, and its incidence is growing[2-4].

In general, liver transplantation (LT) is the best treatment for early-stage HCC, since it simultaneously treats the tumor and the underlying liver disease (the main risk factor for the development of new tumors); thus, the number of patients transplanted for HCC is increasing, with LT for HCC representing 15-50% of all LT performed in most centres[5-7]. Although LT is an outstanding therapy for HCC, due to organ shortage, the careful selection and management of patients who may have a major survival benefit after LT remains a fundamental question. Indeed, the limitation of tumor recurrence after LT is a way to optimize a scarce resource. The present review focuses on current strategies of selection, organ allocation, and management of patients transplanted for HCC.


The milestone study by Mazzaferro in 1996 established deceased donor LT as an important therapeutic strategy for HCC[8]. The study showed that when transplantation was performed in the early-stage of the disease (one nodule ≤ 5 cm or ≤ 3 lesions, none > 3 cm and absence of gross vascular invasion, metastases or lymph nodes involvement), the four-year survival accounted for 75%, with a recurrence rate < 10%-15%. These LT outcomes are not different from those observed in non-HCC cirrhotic subjects. The so called Milan criteria were then widely applied to indicate LT in patients with HCC[8]. However, the Milan criteria are seen as too restrictive and exclude many patients from the transplant list; thus, considerable interest has arisen in their extension[9-13].

As demonstrated by a study held at the University of California in San Francisco (UCSF), HCC patients transplanted with extended criteria corresponding to: (1) Single nodule ≤ 6.5 cm; or (2) ≤ 3 nodules with the largest ≤ 4.5 cm and total sum of diameters ≤ 8cm (UCSF criteria), had an outcome similar to those transplanted within Milan criteria[9]. Nevertheless, a retrospective study by Decaens et al[14], showed that the five-year survival was 45.6% for patients who met the UCSF criteria but not the Milan criteria, and 60.1% for patients who met both criteria. Even if this difference was not statically significant, possibly for a lack of power in the analysis, the trends observed suggest that selection on the base of USCF criteria could be associated with a lower success rate.

In another study, data on 1112 patients who underwent LT for HCC at different centres worldwide, despite exceeding the Milan criteria, were recorded via a web-based survey. Data were analyzed in order to identify tumor features exceeding the Milan criteria but not affecting survival rates. The so-called up-to-seven criteria were identified with this approach. With these criteria the cut-off value is set to seven and the score is calculated by considering the total number of lesions plus the diameter (in cm) of larger nodule (for instance: 4 nodules + larger diameter 3 cm, up-to-seven score = 7). The comparison between patients (n = 283) matching the up-to-seven criteria with subjects (n = 444) transplanted within the canonical Milan criteria did not show significant difference in term of five-year survival after grafting[12]. However, the prognostic value of up-to-seven criteria was inadequate in the presence of microvascular invasion, since the survival rate was significantly worse in comparison with what predicted by the score. Unfortunately, in common clinical practice, the presence of microvascular invasion is not assessable before grafting, thus limiting the routine application of up-to-seven criteria in everyday LT activity.

An interesting way to select LT candidates is based on a composite of the total tumor volume (TTV) and alpha-fetoprotein (AFP) level. Indeed, Toso et al[11] showed in a prospective study that HCC LT candidate selection could be expanded to patients with TTV ≤ 115 cm3 and AFP ≤ 400 ng/mL, without macrovascular invasion or extrahepatic disease. An increased risk of dropout from the waiting list can be expected for these patients, but with a post-transplant survival equivalent to that of patients within the Milan criteria.

Since 2004, the University of Toronto has adopted their proper extended Toronto criteria (ETC). According to this system, transplantation is offered in disregard of any HCC size or number providing that patient does not present extra-hepatic disease extension or a very large tumor poorly differentiated at the pathological examination. In a validation cohort of patients transplanted according to the ETC, the five-year actuarial patient survival from the time of LT was 68%, which is slightly decreased in comparison with that of patients transplanted according to the Milan criteria, but not statistically different. However, HCC recurrence rate was higher in the ETC group[10].

A group from Kyoto proposed the following Kyoto criteria of LT for HCC: ≤ 10 tumors; ≤ 5 cm; and des-gamma-carboxy prothrobine (DCP) ≤ 400 mAU/mL[15]. Using this system, 5 year survival and recurrence rates were 80% and 7%, respectively, when all patients (Milan-in or Kyoto-in) were analysed[13]. Examining the different survival rates according to the adopted heterogeneous selection systems, a question comes to mind: What is the minimum acceptable five-year survival rate in patients undergoing LT for HCC? An expected 50% survival rate at 5 years was suggested as the lowest cut-off for inclusion of a patient on the waiting list[16,17]. However, in a study regarding the competitive allocation of grafts between HCC and non-HCC patients, using a Markow model, a minimal five-year survival rate of 61% for HCC LT was proposed to avoid disadvantage to non-HCC patients on the waiting list[18]. In fact, at a 2010 conference on HCC and transplantation, held in Zurich, a 50% five-year survival was regarded as unsatisfactory[19]. Milan criteria are, at present, the gold standard to select HCC patients for a successful LT and the reference to assess the validity of other suggested criteria[20].

Alternative expanded criteria for HCC LT did not reach a consensus nowadays, and the question remains outstanding and closely linked to the length of the waiting list, the system of allocation of organs, and availability of alternative sources of grafts (such as living donors, domino LT, and marginal organs). Characteristics and results of the different allocation systems adopted for LT in HCC are summarized in Table 1.

Table 1 Characteristics and results of the different allocation systems adopted for liver transplantation in hepatocellular carcinoma.
Selection systemYear of proposalCriteriaSurvival/years of follow-up
Milan criteria1996Single lesion ≤ 5 cm; up to three separate lesions, none larger than 3 cm; no evidence of gross vascular invasion; and no regional nodal or distant metastases85%/4[8]
University of California, San Francisco criteria2007Single nodule up to 6.5 cm or up to three lesions, the largest of which is 4.5 cm or smaller and the sum of the diameters no larger than 8 cm80.9%/5[9]
Up-to-seven criteria2009Sum of size (in cm) of larger tumor plus number of tumors ≤ 771.2%/5[12]
Total tumor volume and alpha-fetoprotein criteria2009Total tumor volume ≤ 115 cm3 and alpha-fetoprotein ≤ 400 ng/mL, without macrovascular invasion or extrahepatic disease74.6%/4[11]
Kyoto criteria2013≤ 10 tumors; ≤ 5 cm; and des-gamma-carboxy prothrobine ≤ 400 mAU/mL65%/5[13]
Extended Toronto criteria2016Any size or number of tumors, without systemic cancer-related symptoms, extrahepatic disease, vascular invasion, or a poorly differentiated largest lesion at percutaneous tumor biopsy.68%/5[10]

The limited availability of donor livers has determined the adoption of criteria, whereby LT priority is based on the risk of wait-list mortality. The model for end-stage liver disease (MELD) score[21], a statistical model that considers the international normalized prothrombin ratio and bilirubin and creatinine serum levels, has been adopted in most allocation systems worldwide. According to this scoring system, higher scores identify patients with a worse short-term prognosis[22].

For patients with HCC, the traditional MELD score is of scarce utility. The original criteria were in fact designed to predict mortality in subjects with end-stage liver cirrhosis rather than subjects affected by a liver neoplasm. Many HCC patients have well-compensated liver disease, characterized by a low MELD score, and their dropout risk from the waiting list is mainly related to progression of the tumor rather than occurrence of liver failure. For these reasons, modified scoring systems with respect to HCC have been developed and adopted by different centres. This policy was engaged to include the same waiting list patients with neoplasm and patients with liver failure without disadvantage to one group or the other. Prioritization scores for patients with HCC are based mainly upon the characteristics of the tumor (size, number, and AFP level) and the waiting time (additional points are given to patients who have had longer waiting periods)[23].

All allocation systems should undergo a constant assessment and revision during time, in order to accomplish their targets with respect to transplant benefits[24]. The system for HCC allocation can be regarded as a “dynamic issue” to be modified in the various geographic areas over time according to the candidate, type of disease, and donor pool characteristics.


Management of patients with HCC on the waiting list aims to avoid disease progression with possible exclusion from grafting. Despite the lack of data from randomized placebo-controlled trials, the recent European guidelines recommend neoadjuvant therapies to reduce the dropout risk due to tumor progression. This strategy is especially suggested when the expected waiting time is six months or longer[20].

Updated guidelines from the American Association for the Study of Liver Disease (AASLD) suggest some form of bridging therapy in patients listed for LT within T2 (Milan criteria) without considering the estimated time on the waiting list; however, there is no recommendation for one particular form of neoadjuvant therapy. For patients with cirrhosis awaiting LT who develop a T1 HCC (a single nodule ≤ 1.9 cm), observation with follow-up imaging is suggested prior to any bridging treatment[25].

The rationale for bridging therapy is evident, since the dropout rate from list, related to tumor extension, is reported to occur in 10%-20% of cases[26-28]. Moreover, further positive effects of neoadjuvant therapy may be expected in this clinical setting[29]. In fact, in patients with HCC response (intended as complete or ≥ 60% tumor necrosis) after locoregional therapy, an improved LT outcome has been described by uncontrolled studies[30,31]. The possible beneficial effect of bridging therapy, in HCC patients waiting a short time in list, remains however, to be established[32]. Given the heterogeneity of populations and therapeutic criteria observed in the different research protocols, is not possible to draw a definitive conclusion on the net effect of bridging therapy for HCC. On the other hand, since beneficial effects were frequently reported, it seems wise to consider this option in HCC patients on waiting list[33,34].

Unfortunately, no randomized controlled trials are available regarding this issue. Bridging therapy depends on the tumor location, size, number, and hepatic function and includes liver resection, percutaneous ethanol injection (PEI), radiofrequency ablation (RFA), microwave ablation, trans-arterial chemoembolization (TACE), radio-embolization, and stereotactic radiotherapy.

The overall results of bridging with TACE are rather inconsistent. Some studies described a clinical benefit without a negative impact on post-transplantation survival[35,36]. One of the most positive studies enrolled 48 patients within the Milan criteria; none of the patients treated with TACE had tumor progression or were withdrawn from the waiting list. Furthermore, the five-year survival after LT was 93%. One hundred and seventy-eight days was the mean waiting time for grafting[35]. In contrast, TACE benefit resulted uncertain in other studies[37,38]. A systematic review concluded that good quality evidence was not available to indicate that TACE: (1) Improved post-LT survival; or (2) Modified LT complication; or (3) In–list dropout rates[39].

For selected patients with small tumors and adequate liver function, another strategy may be pursued, consisting of initial surgical tumor resection followed by close surveillance, and "salvage" transplantation if tumor recurrence or deterioration of liver function occur. In a retrospective analysis of HCC patients undergoing LT as compared with others submitted to initial resection and then LT (due to recurrent HCC, or progression to end-stage liver disease), the surgical procedure, the postoperative course and the overall or disease-free survival were not different[40].

Conversely, a French observational study on salvage LT after initial resection reported an increase in operative mortality and HCC recurrence. Moreover, a worse five-year overall and disease-free survival, as compared with primary LT, was observed. The authors concluded that, even when HCC is amenable of resection, LT still remains the ideal option for a cirrhotic patient with HCC[41]. For all the above, even if a definitive indication should not be drawn, initial tumor resection in patients with well-preserved liver function appears to be a reasonable approach[42-44].

PEI, RFA, and microwave ablation have also been studied as bridging therapies[45-47]. When RFA was employed in fifty-two patients as a bridging therapy, encouraging results were observed. Three patients only (5.8%) dropped out from list, due to tumor progression (mean time in list in the study = 13 mo). Forty-one patients underwent LT with one- and three-year survival rates of 85% and 76%, respectively. HCC recurrence during follow-up did not occur in any patient[45]. Microwave ablation has also been successfully applied as a bridging therapy, although less data are available[48].

Few data are available on radioembolization with yttrium 90-labeled microspheres in comparison with other techniques, however, this procedure has been shown to limit tumor progression and dropout from transplantation programs[49]. The experience with stereotactic body radiotherapy (SBRT) as a bridging therapy is limited, but encouraging. One study compared SBRT with TACE and RFA with respect to dropout rate, postoperative complications, and one-, three- and five-year survival rates after LT. The results were similar among the groups[50].


The majority of treatments used as bridging therapies have also been employed as downstaging therapies. For a comparison see Table 2. “Downstaging” describes treatment used to bring patients within acceptable criteria when their tumor burden exceeds the standard criteria for LT.

Table 2 Techniques employed for bridging or downstaging patients with hepatocellular carcinoma before liver transplantation and their efficacy.
TACE0-35% (39)24%-77% (57)
RadioembolizationNA (49)11%-43% (57)
RFA16.8% (50)NA
SBRT16.7% (50)NA
ResectionNA (40, 42)NA
Combined approach (TACE + RFA or radioembolization)NA56% (58)

Several studies have demonstrated that successful downstaging of HCC to within Milan criteria reduces tumor recurrence with a survival rate, after grafting, comparable with those meeting the Milan criteria at the beginning[51-54]. Regarding this setting, a recent study in 276 patients undergoing locoregional treatment prior to LT showed that a remnant vital tissue ≥ 2 cm was an important predictor of post-LT recurrence[55,56].

There is no universal agreement on the optimal method for downstaging; most of the data have been gathered on TACE or radioembolization. A systematic review on downstaging for HCC, including the data of 950 patients, showed an overall success rate of 48% (95% confidence interval 39%-58%). The difference between TACE and radioembolization was not statistically significant[57]. Other reports have achieved higher success rates (60%) combining different strategies (TACE plus either RFA or radioembolization)[58]. Interestingly, the response to downstaging is an important indirect marker of the biological aggressiveness of the tumor[59].

There is no consensus regarding list-priority of patients re-entering the accepted criteria for LT after downstaging. An Italian consensus conference on liver allocation proposed prioritization according to the risk of progression and the response to bridging/downstaging therapies[60]. Guidelines for treatment of HCC from the AASLD suggest that patients beyond the Milan criteria (≥ T3) should be considered for grafting after an effective downstage of the disease[25].


HCC tumor recurrence following LT is estimated to be approximately 8%-20%[8,10,61,62]. A multicentre study on explant pathology staging showed that the risk of HCC recurrence is higher when the criteria for size or number of HCC are more expanded[12]. Tumor recurrence is mostly extrahepatic (lungs and bones) [63,64] and likely due to the growth of occult metastases[65]. Tumor-related variables appear to be associated with prognosis following LT. Size and number of tumors[9,11], tumor marker serum levels, such as AFP[66] and DCP[67], and inflammation index (neutrophil-to-lymphocyte ratio)[68] have been related to recurrence.

Several studies have analyzed the tumor features in the explanted livers that could influence the development of HCC recurrence; unfortunately, these parameters cannot be used in the pre-transplant setting. In fact, in current clinical practice, the majority of HCC diagnoses are obtained based on radiological findings. The most relevant characteristics of explant pathology are micro- and macroscopic vascular invasion, satellite lesions, and tumor differentiation[69,70].

Investigators at the University of California, San Francisco, have developed a prognostic scoring system [Risk Estimation of Tumor Recurrence After Transplant (RETREAT)] using data from 721 patients who met the Milan criteria. Three variables were independently associated with disease recurrence: microvascular invasion, serum AFP level at the time of transplantation, and diameter of the largest nodule plus the total number of nodules on the explanted liver. These parameters defined a scoring system with the aim of predicting the one- and five-year HCC recurrence risk. The RETREAT score was able to estimate the probability of recurrence, with a risk < 3% corresponding to a score = 0 and ≥ 75% with a score ≥ 5[71].

Concern was raised by a Spanish study in which a temporal association between hepatitis C virus (HCV) therapy employing direct-acting antivirals (DAAs) and recurrent disease was noted in patients previously resected or ablated for HCC[72]. However, more recently, a large prospective study in HCV patients with compensated or decompensated cirrhosis found that the sustained virological response after DAA treatment decreases the incidence of HCC after a mean follow-up time of 14 mo[73]. Therefore, based on these findings, treatment of HCV infection is presently recommended in HCC patients waiting for LT.

A role in HCC recurrence is also played by immunosuppressive regimens containing calcineurin inhibitors, such as tacrolimus and cyclosporine (CSA)[74,75]. It is possible to hypothesize that over-exposure to these drugs soon after LT may inhibit the immune system and prevent the detection and elimination of residual HCC cells[76]. In a retrospective review of HCC patients (n = 70) undergoing transplant and receiving CSA as immunosuppressant, increased serum CSA levels were observed in those who had recurrent disease in comparison with the others[74].


Inhibitors of the mammalian target of rapamycin (mTOR) pathways, sirolimus and everolimus, are immunosuppressive agents that display intriguing properties in the setting of HCC. In vitro and in vivo studies suggest that this class of drug counteracts HCC proliferative activity, probably interfering with vascular endothelial growth factor. Sirolimus has been demonstrated to inhibit the growth and metastatic progression of HCC[77,78]. Several single-institution retrospective and case-control studies reported a reduced tumor recurrence in patients with HCC treated with sirolimus in comparison with those treated with other types of immunosuppressive agents[79-81].

A meta-analysis based on the available data, stated that the use of a sirolimus-based immunosuppression significantly decreases overall tumor recurrence and recurrence-related mortality[82]. However, a prospective phase III international multicentre randomized-controlled trial has given negative results. In this randomized study, HCC patients were allocated to a sirolimus or a sirolimus-free regimens following LT. The five-year disease-free survival was not different between groups[83].

Adjuvant therapy may theoretically represent a benefit for HCC subjects undergoing LT. In fact LT surgery requires extensive manipulation of recipient graft thus exposing the patient to a significant risk of tumor cells seeding. Moreover, after LT immunosuppressed state may enhance tumor growth; when this occurs, post-transplantation recurrence tends to develop more rapidly following LT rather than after resection[84]. However, chemotherapy with drugs, such as cisplatin or 5-fluorouracil, did not show any clear benefit[85-87].

Sorafenib, an oral multitargeted tyrosine kinase inhibitor counteracting HCC neo-angiogenesis, cell proliferation and tumor survival, is the recommended therapy for advanced tumor[88]. A small retrospective case-control match analysis appeared to demonstrate the safety and a potential effect of this molecule in reducing HCC recurrence after grafting thus improving disease-free and overall survival rates when administered in high-risk LT subjects[89]. Nevertheless, a phase III double-blinded placebo-controlled trial of sorafenib versus placebo as an adjuvant therapy for HCC after resection or ablation, did not show any significant effect[90]. Several other active agents have been identified, and in some cases approved, for the treatment of advanced HCC, such as regorafenib, nivolumab, and lenvatinib[91-93], but none of these drugs have been investigated as adjuvant therapies.


LT is an important curative option for patients with early-stage HCC; nevertheless, organ shortage imposes careful selection of patients. Although a growing interest in admitting patients with larger tumors to LT is understandable, the Milan criteria remains the cornerstone to select HCC patients for transplant. Bridging and downstaging therapies are useful for limiting the dropout of patients awaiting LT, even if the benefit has not been proven in controlled trials. The role of immunosuppressive regimens using inhibitors of mTOR in the prevention of recurrence after LT remains controversial. Currently, though several biomarkers have been proposed, no one has proved strong validity to predict tumor recurrence. Extensive research into predictors of recurrence, such as microvascular invasion, could make refinement of selection criteria possible. Encouraging data are coming from molecular analysis of HCC in regard to disease features. A study evidenced a genetic pattern (genetic signature composed by 35 genes) with a negative predictive value of 0.77 for HCC microvascular invasion[94]. Another recent research proposed two prognostic molecular subtypes among patients with HCC with different vascular invasion and tumor differentiation[95]. However, given the heterogeneity of HCC, efforts are to be commended in future to identify consistent prognostic biomarkers before and after LT.


Manuscript source: Invited manuscript

Specialty type: Gastroenterology and hepatology

Country of origin: Italy

Peer-review report classification

Grade A (Excellent): 0

Grade B (Very good): B

Grade C (Good): C

Grade D (Fair): 0

Grade E (Poor): 0

P-Reviewer: Fernandez-Rodriguez CM, Ocker M S-Editor: Yan JP L-Editor: A E-Editor: Ma YJ

1.  IARC. Globocan (2015) Fact sheets by Population-Globocan-IARC [cited 26 January 2019].  Available from: http://globocan.  [PubMed]  [DOI]  [Cited in This Article: ]
2.  El-Serag HB, Davila JA, Petersen NJ, McGlynn KA. The continuing increase in the incidence of hepatocellular carcinoma in the United States: An update. Ann Intern Med. 2003;139:817-823.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 714]  [Cited by in F6Publishing: 758]  [Article Influence: 36.1]  [Reference Citation Analysis (0)]
3.  Ince N, Wands JR. The increasing incidence of hepatocellular carcinoma. N Engl J Med. 1999;340:798-799.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 113]  [Cited by in F6Publishing: 109]  [Article Influence: 4.4]  [Reference Citation Analysis (0)]
4.  El-Serag HB, Kanwal F. Epidemiology of hepatocellular carcinoma in the United States: Where are we? Where do we go? Hepatology. 2014;60:1767-1775.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 475]  [Cited by in F6Publishing: 454]  [Article Influence: 45.4]  [Reference Citation Analysis (0)]
5.  Adam R, Karam V, Delvart V, O'Grady J, Mirza D, Klempnauer J, Castaing D, Neuhaus P, Jamieson N, Salizzoni M, Pollard S, Lerut J, Paul A, Garcia-Valdecasas JC, Rodríguez FS, Burroughs A; All contributing centers (www.; European Liver and Intestine Transplant Association (ELITA). Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR). J Hepatol. 2012;57:675-688.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 606]  [Cited by in F6Publishing: 599]  [Article Influence: 49.9]  [Reference Citation Analysis (1)]
6.  Kim WR, Lake JR, Smith JM, Skeans MA, Schladt DP, Edwards EB, Harper AM, Wainright JL, Snyder JJ, Israni AK, Kasiske BL. OPTN/SRTR 2013 Annual Data Report: Liver. Am J Transplant. 2015;15 Suppl 2:1-28.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 245]  [Cited by in F6Publishing: 242]  [Article Influence: 26.9]  [Reference Citation Analysis (0)]
7.  de Villa V, Lo CM. Liver transplantation for hepatocellular carcinoma in Asia. Oncologist. 2007;12:1321-1331.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 88]  [Cited by in F6Publishing: 97]  [Article Influence: 6.1]  [Reference Citation Analysis (0)]
8.  Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, Montalto F, Ammatuna M, Morabito A, Gennari L. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693-699.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 5110]  [Cited by in F6Publishing: 5052]  [Article Influence: 180.4]  [Reference Citation Analysis (0)]
9.  Yao FY, Xiao L, Bass NM, Kerlan R, Ascher NL, Roberts JP. Liver transplantation for hepatocellular carcinoma: Validation of the UCSF-expanded criteria based on preoperative imaging. Am J Transplant. 2007;7:2587-2596.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 382]  [Cited by in F6Publishing: 399]  [Article Influence: 23.5]  [Reference Citation Analysis (0)]
10.  Sapisochin G, Goldaracena N, Laurence JM, Dib M, Barbas A, Ghanekar A, Cleary SP, Lilly L, Cattral MS, Marquez M, Selzner M, Renner E, Selzner N, McGilvray ID, Greig PD, Grant DR. The extended Toronto criteria for liver transplantation in patients with hepatocellular carcinoma: A prospective validation study. Hepatology. 2016;64:2077-2088.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 197]  [Cited by in F6Publishing: 233]  [Article Influence: 29.1]  [Reference Citation Analysis (0)]
11.  Toso C, Meeberg G, Hernandez-Alejandro R, Dufour JF, Marotta P, Majno P, Kneteman NM. Total tumor volume and alpha-fetoprotein for selection of transplant candidates with hepatocellular carcinoma: A prospective validation. Hepatology. 2015;62:158-165.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 161]  [Cited by in F6Publishing: 203]  [Article Influence: 22.6]  [Reference Citation Analysis (0)]
12.  Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, Camerini T, Roayaie S, Schwartz ME, Grazi GL, Adam R, Neuhaus P, Salizzoni M, Bruix J, Forner A, De Carlis L, Cillo U, Burroughs AK, Troisi R, Rossi M, Gerunda GE, Lerut J, Belghiti J, Boin I, Gugenheim J, Rochling F, Van Hoek B, Majno P; Metroticket Investigator Study Group. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: A retrospective, exploratory analysis. Lancet Oncol. 2009;10:35-43.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1267]  [Cited by in F6Publishing: 1448]  [Article Influence: 90.5]  [Reference Citation Analysis (1)]
13.  Kaido T, Ogawa K, Mori A, Fujimoto Y, Ito T, Tomiyama K, Takada Y, Uemoto S. Usefulness of the Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinoma. Surgery. 2013;154:1053-1060.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 91]  [Cited by in F6Publishing: 122]  [Article Influence: 11.1]  [Reference Citation Analysis (0)]
14.  Decaens T, Roudot-Thoraval F, Hadni-Bresson S, Meyer C, Gugenheim J, Durand F, Bernard PH, Boillot O, Sulpice L, Calmus Y, Hardwigsen J, Ducerf C, Pageaux GP, Dharancy S, Chazouilleres O, Cherqui D, Duvoux C. Impact of UCSF criteria according to pre- and post-OLT tumor features: Analysis of 479 patients listed for HCC with a short waiting time. Liver Transpl. 2006;12:1761-1769.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 141]  [Cited by in F6Publishing: 138]  [Article Influence: 7.7]  [Reference Citation Analysis (0)]
15.  Takada Y, Ito T, Ueda M, Sakamoto S, Haga H, Maetani Y, Ogawa K, Ogura Y, Oike F, Egawa H, Uemoto S. Living donor liver transplantation for patients with HCC exceeding the Milan criteria: A proposal of expanded criteria. Dig Dis. 2007;25:299-302.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 88]  [Cited by in F6Publishing: 89]  [Article Influence: 5.2]  [Reference Citation Analysis (0)]
16.  Navasa M, Bruix J. Multifaceted perspective of the waiting list for liver transplantation: The value of pharmacokinetic models. Hepatology. 2010;51:12-15.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 23]  [Cited by in F6Publishing: 31]  [Article Influence: 2.2]  [Reference Citation Analysis (0)]
17.  Bruix J, Fuster J, Llovet JM. Liver transplantation for hepatocellular carcinoma: Foucault pendulum versus evidence-based decision. Liver Transpl. 2003;9:700-702.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 90]  [Cited by in F6Publishing: 93]  [Article Influence: 4.4]  [Reference Citation Analysis (0)]
18.  Volk ML, Vijan S, Marrero JA. A novel model measuring the harm of transplanting hepatocellular carcinoma exceeding Milan criteria. Am J Transplant. 2008;8:839-846.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 149]  [Cited by in F6Publishing: 149]  [Article Influence: 9.3]  [Reference Citation Analysis (0)]
19.  Clavien PA, Lesurtel M, Bossuyt PM, Gores GJ, Langer B, Perrier A; OLT for HCC Consensus Group. Recommendations for liver transplantation for hepatocellular carcinoma: An international consensus conference report. Lancet Oncol. 2012;13:e11-e22.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 761]  [Cited by in F6Publishing: 739]  [Article Influence: 61.6]  [Reference Citation Analysis (1)]
20.  European Association for the Study of the Liver. Electronic address:; European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018;69:182-236.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 3934]  [Cited by in F6Publishing: 5141]  [Article Influence: 856.8]  [Reference Citation Analysis (0)]
21.  Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology. 2000;31:864-871.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1967]  [Cited by in F6Publishing: 1938]  [Article Influence: 80.8]  [Reference Citation Analysis (0)]
22.  Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P, Kremers W, Lake J, Howard T, Merion RM, Wolfe RA, Krom R; United Network for Organ Sharing Liver Disease Severity Score Committee. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology. 2003;124:91-96.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1825]  [Cited by in F6Publishing: 1783]  [Article Influence: 84.9]  [Reference Citation Analysis (0)]
23.  Toso C, Mazzaferro V, Bruix J, Freeman R, Mentha G, Majno P. Toward a better liver graft allocation that accounts for candidates with and without hepatocellular carcinoma. Am J Transplant. 2014;14:2221-2227.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 45]  [Cited by in F6Publishing: 45]  [Article Influence: 4.5]  [Reference Citation Analysis (0)]
24.  Lamas D, Rosenbaum L. Very complicated math--reconfiguring organ allocation. N Engl J Med. 2014;371:2447-2450.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 9]  [Cited by in F6Publishing: 9]  [Article Influence: 0.9]  [Reference Citation Analysis (0)]
25.  Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, Zhu AX, Murad MH, Marrero JA. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67:358-380.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 2107]  [Cited by in F6Publishing: 2666]  [Article Influence: 444.3]  [Reference Citation Analysis (2)]
26.  Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation. Hepatology. 1999;30:1434-1440.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1331]  [Cited by in F6Publishing: 1393]  [Article Influence: 55.7]  [Reference Citation Analysis (0)]
27.  Yao FY, Bass NM, Nikolai B, Merriman R, Davern TJ, Kerlan R, Ascher NL, Roberts JP. A follow-up analysis of the pattern and predictors of dropout from the waiting list for liver transplantation in patients with hepatocellular carcinoma: Implications for the current organ allocation policy. Liver Transpl. 2003;9:684-692.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 206]  [Cited by in F6Publishing: 213]  [Article Influence: 10.1]  [Reference Citation Analysis (0)]
28.  Majno P, Lencioni R, Mornex F, Girard N, Poon RT, Cherqui D. Is the treatment of hepatocellular carcinoma on the waiting list necessary? Liver Transpl. 2011;17 Suppl 2:S98-108.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 54]  [Cited by in F6Publishing: 58]  [Article Influence: 4.5]  [Reference Citation Analysis (0)]
29.  Lin Y, Chapman WC. Towards more effective liver allocation criteria for hepatocellular carcinoma: Tumor response to locoregional therapy. Ann Surg Oncol. 2011;18:2416-2418.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1]  [Cited by in F6Publishing: 1]  [Article Influence: 0.1]  [Reference Citation Analysis (0)]
30.  Bharat A, Brown DB, Crippin JS, Gould JE, Lowell JA, Shenoy S, Desai NM, Chapman WC. Pre-liver transplantation locoregional adjuvant therapy for hepatocellular carcinoma as a strategy to improve longterm survival. J Am Coll Surg. 2006;203:411-420.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 95]  [Cited by in F6Publishing: 83]  [Article Influence: 4.6]  [Reference Citation Analysis (0)]
31.  Chan KM, Yu MC, Chou HS, Wu TJ, Lee CF, Lee WC. Significance of tumor necrosis for outcome of patients with hepatocellular carcinoma receiving locoregional therapy prior to liver transplantation. Ann Surg Oncol. 2011;18:2638-2646.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 25]  [Cited by in F6Publishing: 33]  [Article Influence: 2.5]  [Reference Citation Analysis (0)]
32.  Sourianarayanane A, El-Gazzaz G, Sanabria JR, Menon KV, Quintini C, Hashimoto K, Kelly D, Eghtesad B, Miller C, Fung J, Aucejo F. Loco-regional therapy in patients with Milan Criteria-compliant hepatocellular carcinoma and short waitlist time to transplant: An outcome analysis. HPB (Oxford). 2012;14:325-332.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 10]  [Cited by in F6Publishing: 12]  [Article Influence: 1.0]  [Reference Citation Analysis (0)]
33.  Aloia TA, Adam R, Samuel D, Azoulay D, Castaing D. A decision analysis model identifies the interval of efficacy for transarterial chemoembolization (TACE) in cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation. J Gastrointest Surg. 2007;11:1328-1332.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 22]  [Cited by in F6Publishing: 22]  [Article Influence: 1.3]  [Reference Citation Analysis (0)]
34.  Llovet JM, Mas X, Aponte JJ, Fuster J, Navasa M, Christensen E, Rodés J, Bruix J. Cost effectiveness of adjuvant therapy for hepatocellular carcinoma during the waiting list for liver transplantation. Gut. 2002;50:123-128.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 210]  [Cited by in F6Publishing: 224]  [Article Influence: 10.2]  [Reference Citation Analysis (0)]
35.  Graziadei IW, Sandmueller H, Waldenberger P, Koenigsrainer A, Nachbaur K, Jaschke W, Margreiter R, Vogel W. Chemoembolization followed by liver transplantation for hepatocellular carcinoma impedes tumor progression while on the waiting list and leads to excellent outcome. Liver Transpl. 2003;9:557-563.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 347]  [Cited by in F6Publishing: 326]  [Article Influence: 15.5]  [Reference Citation Analysis (0)]
36.  Manini MA, Sangiovanni A, Martinetti L, Viganò D, La Mura V, Aghemo A, Iavarone M, Crespi S, Nicolini A, Colombo M. Transarterial chemoembolization with drug-eluting beads is effective for the maintenance of the Milan-in status in patients with a small hepatocellular carcinoma. Liver Transpl. 2015;21:1259-1269.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 30]  [Cited by in F6Publishing: 32]  [Article Influence: 3.6]  [Reference Citation Analysis (0)]
37.  Oldhafer KJ, Chavan A, Frühauf NR, Flemming P, Schlitt HJ, Kubicka S, Nashan B, Weimann A, Raab R, Manns MP, Galanski M. Arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma: Marked tumor necrosis, but no survival benefit? J Hepatol. 1998;29:953-959.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 118]  [Cited by in F6Publishing: 118]  [Article Influence: 4.5]  [Reference Citation Analysis (0)]
38.  Decaens T, Roudot-Thoraval F, Bresson-Hadni S, Meyer C, Gugenheim J, Durand F, Bernard PH, Boillot O, Boudjema K, Calmus Y, Hardwigsen J, Ducerf C, Pageaux GP, Dharancy S, Chazouilleres O, Dhumeaux D, Cherqui D, Duvoux C. Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma. Liver Transpl. 2005;11:767-775.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 170]  [Cited by in F6Publishing: 159]  [Article Influence: 8.4]  [Reference Citation Analysis (0)]
39.  Lesurtel M, Müllhaupt B, Pestalozzi BC, Pfammatter T, Clavien PA. Transarterial chemoembolization as a bridge to liver transplantation for hepatocellular carcinoma: An evidence-based analysis. Am J Transplant. 2006;6:2644-2650.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 131]  [Cited by in F6Publishing: 138]  [Article Influence: 7.7]  [Reference Citation Analysis (0)]
40.  Belghiti J, Cortes A, Abdalla EK, Régimbeau JM, Prakash K, Durand F, Sommacale D, Dondero F, Lesurtel M, Sauvanet A, Farges O, Kianmanesh R. Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg. 2003;238:885-92; discussion 892-3.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 320]  [Cited by in F6Publishing: 342]  [Article Influence: 16.3]  [Reference Citation Analysis (0)]
41.  Adam R, Azoulay D, Castaing D, Eshkenazy R, Pascal G, Hashizume K, Samuel D, Bismuth H. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: A reasonable strategy? Ann Surg. 2003;238:508-18; discussion 518-9.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 212]  [Cited by in F6Publishing: 236]  [Article Influence: 11.2]  [Reference Citation Analysis (0)]
42.  Majno PE, Sarasin FP, Mentha G, Hadengue A. Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: An outcome-oriented decision analysis. Hepatology. 2000;31:899-906.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 244]  [Cited by in F6Publishing: 254]  [Article Influence: 10.6]  [Reference Citation Analysis (0)]
43.  Hu Z, Zhou J, Xu X, Li Z, Zhou L, Wu J, Zhang M, Zheng S. Salvage liver transplantation is a reasonable option for selected patients who have recurrent hepatocellular carcinoma after liver resection. PLoS One. 2012;7:e36587.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 30]  [Cited by in F6Publishing: 32]  [Article Influence: 2.7]  [Reference Citation Analysis (0)]
44.  Fuks D, Dokmak S, Paradis V, Diouf M, Durand F, Belghiti J. Benefit of initial resection of hepatocellular carcinoma followed by transplantation in case of recurrence: An intention-to-treat analysis. Hepatology. 2012;55:132-140.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 196]  [Cited by in F6Publishing: 224]  [Article Influence: 18.7]  [Reference Citation Analysis (0)]
45.  Lu DS, Yu NC, Raman SS, Lassman C, Tong MJ, Britten C, Durazo F, Saab S, Han S, Finn R, Hiatt JR, Busuttil RW. Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation. Hepatology. 2005;41:1130-1137.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 257]  [Cited by in F6Publishing: 256]  [Article Influence: 13.5]  [Reference Citation Analysis (0)]
46.  Castroagudín JF, Delgado M, Villanueva A, Bustamante M, Martínez J, Otero E, Tomé S, Martínez SM, Segade FR, Conde R, Dominguez-Muñoz E, Varo E. Safety of percutaneous ethanol injection as neoadjuvant therapy for hepatocellular carcinoma in waiting list liver transplant candidates. Transplant Proc. 2005;37:3871-3873.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 13]  [Cited by in F6Publishing: 17]  [Article Influence: 0.9]  [Reference Citation Analysis (0)]
47.  Pompili M, Mirante VG, Rondinara G, Fassati LR, Piscaglia F, Agnes S, Covino M, Ravaioli M, Fagiuoli S, Gasbarrini G, Rapaccini GL. Percutaneous ablation procedures in cirrhotic patients with hepatocellular carcinoma submitted to liver transplantation: Assessment of efficacy at explant analysis and of safety for tumor recurrence. Liver Transpl. 2005;11:1117-1126.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 150]  [Cited by in F6Publishing: 166]  [Article Influence: 8.7]  [Reference Citation Analysis (0)]
48.  Zanus G, Boetto R, Gringeri E, Vitale A, D'Amico F, Carraro A, Bassi D, Bonsignore P, Noaro G, Mescoli C, Rugge M, Angeli P, Senzolo M, Burra P, Feltracco P, Cillo U. Microwave thermal ablation for hepatocarcinoma: Six liver transplantation cases. Transplant Proc. 2011;43:1091-1094.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 19]  [Cited by in F6Publishing: 21]  [Article Influence: 1.6]  [Reference Citation Analysis (0)]
49.  Kulik LM, Atassi B, van Holsbeeck L, Souman T, Lewandowski RJ, Mulcahy MF, Hunter RD, Nemcek AA, Abecassis MM, Haines KG, Salem R. Yttrium-90 microspheres (TheraSphere) treatment of unresectable hepatocellular carcinoma: Downstaging to resection, RFA and bridge to transplantation. J Surg Oncol. 2006;94:572-586.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 249]  [Cited by in F6Publishing: 236]  [Article Influence: 13.1]  [Reference Citation Analysis (0)]
50.  Sapisochin G, Barry A, Doherty M, Fischer S, Goldaracena N, Rosales R, Russo M, Beecroft R, Ghanekar A, Bhat M, Brierley J, Greig PD, Knox JJ, Dawson LA, Grant DR. Stereotactic body radiotherapy vs. TACE or RFA as a bridge to transplant in patients with hepatocellular carcinoma. An intention-to-treat analysis. J Hepatol. 2017;67:92-99.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 152]  [Cited by in F6Publishing: 192]  [Article Influence: 27.4]  [Reference Citation Analysis (0)]
51.  Chapman WC, Majella Doyle MB, Stuart JE, Vachharajani N, Crippin JS, Anderson CD, Lowell JA, Shenoy S, Darcy MD, Brown DB. Outcomes of neoadjuvant transarterial chemoembolization to downstage hepatocellular carcinoma before liver transplantation. Ann Surg. 2008;248:617-625.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 221]  [Cited by in F6Publishing: 225]  [Article Influence: 14.1]  [Reference Citation Analysis (0)]
52.  Jang JW, You CR, Kim CW, Bae SH, Yoon SK, Yoo YK, Kim DG, Choi JY. Benefit of downsizing hepatocellular carcinoma in a liver transplant population. Aliment Pharmacol Ther. 2010;31:415-423.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 58]  [Cited by in F6Publishing: 47]  [Article Influence: 3.4]  [Reference Citation Analysis (0)]
53.  Ravaioli M, Grazi GL, Piscaglia F, Trevisani F, Cescon M, Ercolani G, Vivarelli M, Golfieri R, D'Errico Grigioni A, Panzini I, Morelli C, Bernardi M, Bolondi L, Pinna AD. Liver transplantation for hepatocellular carcinoma: Results of down-staging in patients initially outside the Milan selection criteria. Am J Transplant. 2008;8:2547-2557.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 263]  [Cited by in F6Publishing: 284]  [Article Influence: 17.8]  [Reference Citation Analysis (0)]
54.  Yao FY, Mehta N, Flemming J, Dodge J, Hameed B, Fix O, Hirose R, Fidelman N, Kerlan RK, Roberts JP. Downstaging of hepatocellular cancer before liver transplant: Long-term outcome compared to tumors within Milan criteria. Hepatology. 2015;61:1968-1977.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 290]  [Cited by in F6Publishing: 324]  [Article Influence: 36.0]  [Reference Citation Analysis (0)]
55.  Manzia TM, Lai Q, Iesari S, Perera MTPR, Komuta M, Carvalheiro A, Shah T, Angelico R, Quaranta C, Nicolini D, Montalti R, Scarpelli M, Palmieri G, Orlacchio A, Vivarelli M, Angelico M, Lerut J, Tisone G. Impact of remnant vital tissue after locoregional treatment and liver transplant in hepatocellular cancer patients, a multicentre cohort study. Transpl Int. 2018;.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 14]  [Cited by in F6Publishing: 15]  [Article Influence: 2.5]  [Reference Citation Analysis (0)]
56.  Rubin A, Berenguer M. Remnant vital tissue following locoregional therapy for hepatocellular carcinoma: Another player in the game. Transpl Int. 2018;.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1]  [Cited by in F6Publishing: 1]  [Article Influence: 0.2]  [Reference Citation Analysis (0)]
57.  Parikh ND, Waljee AK, Singal AG. Downstaging hepatocellular carcinoma: A systematic review and pooled analysis. Liver Transpl. 2015;21:1142-1152.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 152]  [Cited by in F6Publishing: 158]  [Article Influence: 17.6]  [Reference Citation Analysis (0)]
58.  Barakat O, Wood RP, Ozaki CF, Ankoma-Sey V, Galati J, Skolkin M, Toombs B, Round M, Moore W, Mieles L. Morphological features of advanced hepatocellular carcinoma as a predictor of downstaging and liver transplantation: An intention-to-treat analysis. Liver Transpl. 2010;16:289-299.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 66]  [Cited by in F6Publishing: 73]  [Article Influence: 5.2]  [Reference Citation Analysis (0)]
59.  Cescon M, Cucchetti A, Ravaioli M, Pinna AD. Hepatocellular carcinoma locoregional therapies for patients in the waiting list. Impact on transplantability and recurrence rate. J Hepatol. 2013;58:609-618.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 113]  [Cited by in F6Publishing: 108]  [Article Influence: 9.8]  [Reference Citation Analysis (0)]
60.  Cillo U, Burra P, Mazzaferro V, Belli L, Pinna AD, Spada M, Nanni Costa A, Toniutto P; I-BELT (Italian Board of Experts in the Field of Liver Transplantation). A Multistep, Consensus-Based Approach to Organ Allocation in Liver Transplantation: Toward a "Blended Principle Model". Am J Transplant. 2015;15:2552-2561.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 129]  [Cited by in F6Publishing: 144]  [Article Influence: 16.0]  [Reference Citation Analysis (0)]
61.  Yao FY. Expanded criteria for liver transplantation in patients with hepatocellular carcinoma. Hepatol Res. 2007;37 Suppl 2:S267-S274.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 19]  [Cited by in F6Publishing: 19]  [Article Influence: 1.1]  [Reference Citation Analysis (0)]
62.  Silva MF, Sherman M. Criteria for liver transplantation for HCC: What should the limits be? J Hepatol. 2011;55:1137-1147.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 50]  [Cited by in F6Publishing: 54]  [Article Influence: 4.2]  [Reference Citation Analysis (0)]
63.  Sotiropoulos GC, Molmenti EP, Lösch C, Beckebaum S, Broelsch CE, Lang H. Meta-analysis of tumor recurrence after liver transplantation for hepatocellular carcinoma based on 1,198 cases. Eur J Med Res. 2007;12:527-534.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 57]  [Cited by in F6Publishing: 57]  [Article Influence: 3.4]  [Reference Citation Analysis (0)]
64.  Valdivieso A, Bustamante J, Gastaca M, Uriarte JG, Ventoso A, Ruiz P, Fernandez JR, Pijoan I, Testillano M, Suarez MJ, Montejo M, Ortiz de Urbina J. Management of hepatocellular carcinoma recurrence after liver transplantation. Transplant Proc. 2010;42:660-662.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 69]  [Cited by in F6Publishing: 75]  [Article Influence: 5.4]  [Reference Citation Analysis (0)]
65.  Toso C, Mentha G, Majno P. Liver transplantation for hepatocellular carcinoma: Five steps to prevent recurrence. Am J Transplant. 2011;11:2031-2035.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 82]  [Cited by in F6Publishing: 84]  [Article Influence: 6.5]  [Reference Citation Analysis (0)]
66.  Duvoux C, Roudot-Thoraval F, Decaens T, Pessione F, Badran H, Piardi T, Francoz C, Compagnon P, Vanlemmens C, Dumortier J, Dharancy S, Gugenheim J, Bernard PH, Adam R, Radenne S, Muscari F, Conti F, Hardwigsen J, Pageaux GP, Chazouillères O, Salame E, Hilleret MN, Lebray P, Abergel A, Debette-Gratien M, Kluger MD, Mallat A, Azoulay D, Cherqui D; Liver Transplantation French Study Group. Liver transplantation for hepatocellular carcinoma: A model including α-fetoprotein improves the performance of Milan criteria. Gastroenterology. 2012;143:986-94.e3; quiz e14-5.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 561]  [Cited by in F6Publishing: 655]  [Article Influence: 54.6]  [Reference Citation Analysis (0)]
67.  Fujiki M, Takada Y, Ogura Y, Oike F, Kaido T, Teramukai S, Uemoto S. Significance of des-gamma-carboxy prothrombin in selection criteria for living donor liver transplantation for hepatocellular carcinoma. Am J Transplant. 2009;9:2362-2371.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 113]  [Cited by in F6Publishing: 126]  [Article Influence: 8.4]  [Reference Citation Analysis (0)]
68.  Halazun KJ, Hardy MA, Rana S, Tamura AA, Woodland DC 4th, Luyten EJ, Mahadev S, Witkowski P, WSiegel AB, Brown RS, Emond JC. Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg. 2009;250:141-151.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 265]  [Cited by in F6Publishing: 308]  [Article Influence: 20.5]  [Reference Citation Analysis (0)]
69.  Tamura S, Kato T, Berho M, Misiakos EP, O'Brien C, Reddy KR, Nery JR, Burke GW, Schiff ER, Miller J, Tzakis AG. Impact of histological grade of hepatocellular carcinoma on the outcome of liver transplantation. Arch Surg. 2001;136:25-30; discussion 31.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 193]  [Cited by in F6Publishing: 196]  [Article Influence: 8.5]  [Reference Citation Analysis (0)]
70.  Marsh JW, Dvorchik I, Subotin M, Balan V, Rakela J, Popechitelev EP, Subbotin V, Casavilla A, Carr BI, Fung JJ, Iwatsuki S. The prediction of risk of recurrence and time to recurrence of hepatocellular carcinoma after orthotopic liver transplantation: A pilot study. Hepatology. 1997;26:444-450.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 166]  [Cited by in F6Publishing: 172]  [Article Influence: 6.4]  [Reference Citation Analysis (0)]
71.  Mehta N, Heimbach J, Harnois DM, Sapisochin G, Dodge JL, Lee D, Burns JM, Sanchez W, Greig PD, Grant DR, Roberts JP, Yao FY. Validation of a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) Score for Hepatocellular Carcinoma Recurrence After Liver Transplant. JAMA Oncol. 2017;3:493-500.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 159]  [Cited by in F6Publishing: 229]  [Article Influence: 32.7]  [Reference Citation Analysis (0)]
72.  Reig M, Mariño Z, Perelló C, Iñarrairaegui M, Ribeiro A, Lens S, Díaz A, Vilana R, Darnell A, Varela M, Sangro B, Calleja JL, Forns X, Bruix J. Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy. J Hepatol. 2016;65:719-726.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 725]  [Cited by in F6Publishing: 765]  [Article Influence: 95.6]  [Reference Citation Analysis (0)]
73.  Calvaruso V, Cabibbo G, Cacciola I, Petta S, Madonia S, Bellia A, Tinè F, Distefano M, Licata A, Giannitrapani L, Prestileo T, Mazzola G, Di Rosolini MA, Larocca L, Bertino G, Digiacomo A, Benanti F, Guarneri L, Averna A, Iacobello C, Magro A, Scalisi I, Cartabellotta F, Savalli F, Barbara M, Davì A, Russello M, Scifo G, Squadrito G, Cammà C, Raimondo G, Craxì A, Di Marco V; Rete Sicilia Selezione Terapia–HCV (RESIST-HCV). Incidence of Hepatocellular Carcinoma in Patients With HCV-Associated Cirrhosis Treated With Direct-Acting Antiviral Agents. Gastroenterology. 2018;155:411-421.e4.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 237]  [Cited by in F6Publishing: 249]  [Article Influence: 41.5]  [Reference Citation Analysis (0)]
74.  Vivarelli M, Cucchetti A, Piscaglia F, La Barba G, Bolondi L, Cavallari A, Pinna AD. Analysis of risk factors for tumor recurrence after liver transplantation for hepatocellular carcinoma: Key role of immunosuppression. Liver Transpl. 2005;11:497-503.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 155]  [Cited by in F6Publishing: 166]  [Article Influence: 8.7]  [Reference Citation Analysis (0)]
75.  Rodríguez-Perálvarez M, Tsochatzis E, Naveas MC, Pieri G, García-Caparrós C, O'Beirne J, Poyato-González A, Ferrín-Sánchez G, Montero-Álvarez JL, Patch D, Thorburn D, Briceño J, De la Mata M, Burroughs AK. Reduced exposure to calcineurin inhibitors early after liver transplantation prevents recurrence of hepatocellular carcinoma. J Hepatol. 2013;59:1193-1199.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 137]  [Cited by in F6Publishing: 162]  [Article Influence: 14.7]  [Reference Citation Analysis (0)]
76.  Rodríguez-Perálvarez M, De la Mata M, Burroughs AK. Liver transplantation: immunosuppression and oncology. Curr Opin Organ Transplant. 2014;19:253-260.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 82]  [Cited by in F6Publishing: 72]  [Article Influence: 7.2]  [Reference Citation Analysis (0)]
77.  Wang Z, Zhou J, Fan J, Tan CJ, Qiu SJ, Yu Y, Huang XW, Tang ZY. Sirolimus inhibits the growth and metastatic progression of hepatocellular carcinoma. J Cancer Res Clin Oncol. 2009;135:715-722.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 35]  [Cited by in F6Publishing: 31]  [Article Influence: 1.9]  [Reference Citation Analysis (0)]
78.  Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med. 2002;8:128-135.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 1347]  [Cited by in F6Publishing: 1278]  [Article Influence: 58.1]  [Reference Citation Analysis (0)]
79.  Toso C, Merani S, Bigam DL, Shapiro AM, Kneteman NM. Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma. Hepatology. 2010;51:1237-1243.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 240]  [Cited by in F6Publishing: 237]  [Article Influence: 16.9]  [Reference Citation Analysis (0)]
80.  Zimmerman MA, Trotter JF, Wachs M, Bak T, Campsen J, Skibba A, Kam I. Sirolimus-based immunosuppression following liver transplantation for hepatocellular carcinoma. Liver Transpl. 2008;14:633-638.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 161]  [Cited by in F6Publishing: 174]  [Article Influence: 10.9]  [Reference Citation Analysis (0)]
81.  Angelico R, Parente A, Manzia TM. Using a weaning immunosuppression protocol in liver transplantation recipients with hepatocellular carcinoma: A compromise between the risk of recurrence and the risk of rejection? Transl Gastroenterol Hepatol. 2017;2:74.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 7]  [Cited by in F6Publishing: 9]  [Article Influence: 1.3]  [Reference Citation Analysis (0)]
82.  Menon KV, Hakeem AR, Heaton ND. Meta-analysis: Recurrence and survival following the use of sirolimus in liver transplantation for hepatocellular carcinoma. Aliment Pharmacol Ther. 2013;37:411-419.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 98]  [Cited by in F6Publishing: 97]  [Article Influence: 8.8]  [Reference Citation Analysis (0)]
83.  Geissler EK, Schnitzbauer AA, Zülke C, Lamby PE, Proneth A, Duvoux C, Burra P, Jauch KW, Rentsch M, Ganten TM, Schmidt J, Settmacher U, Heise M, Rossi G, Cillo U, Kneteman N, Adam R, van Hoek B, Bachellier P, Wolf P, Rostaing L, Bechstein WO, Rizell M, Powell J, Hidalgo E, Gugenheim J, Wolters H, Brockmann J, Roy A, Mutzbauer I, Schlitt A, Beckebaum S, Graeb C, Nadalin S, Valente U, Turrión VS, Jamieson N, Scholz T, Colledan M, Fändrich F, Becker T, Söderdahl G, Chazouillères O, Mäkisalo H, Pageaux GP, Steininger R, Soliman T, de Jong KP, Pirenne J, Margreiter R, Pratschke J, Pinna AD, Hauss J, Schreiber S, Strasser S, Klempnauer J, Troisi RI, Bhoori S, Lerut J, Bilbao I, Klein CG, Königsrainer A, Mirza DF, Otto G, Mazzaferro V, Neuhaus P, Schlitt HJ. Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial. Transplantation. 2016;100:116-125.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 245]  [Cited by in F6Publishing: 302]  [Article Influence: 37.8]  [Reference Citation Analysis (0)]
84.  Yokoyama I, Carr B, Saitsu H, Iwatsuki S, Starzl TE. Accelerated growth rates of recurrent hepatocellular carcinoma after liver transplantation. Cancer. 1991;68:2095-2100.  [PubMed]  [DOI]  [Cited in This Article: ]
85.  Söderdahl G, Bäckman L, Isoniemi H, Cahlin C, Höckerstedt K, Broomé U, Mäkisalo H, Friman S, Ericzon BG. A prospective, randomized, multi-centre trial of systemic adjuvant chemotherapy versus no additional treatment in liver transplantation for hepatocellular carcinoma. Transpl Int. 2006;19:288-294.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 59]  [Cited by in F6Publishing: 55]  [Article Influence: 3.1]  [Reference Citation Analysis (0)]
86.  Bassanello M, Vitale A, Ciarleglio FA, Brolese A, Zanus G, D'Amico F, Carraro A, Cappuzzo G, Bridda A, Senzolo M, Burra P, Pevere S, D'Amico D, Cillo U. Adjuvant chemotherapy for transplanted hepatocellular carcinoma patients: Impact on survival or HCV recurrence timing. Transplant Proc. 2003;35:2991-2994.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 16]  [Cited by in F6Publishing: 12]  [Article Influence: 0.6]  [Reference Citation Analysis (0)]
87.  Bernal E, Montero JL, Delgado M, Fraga E, Costán G, Barrera P, López-Vallejos P, Solórzano G, Rufián S, Briceño J, Padillo J, López-Cillero P, Marchal T, Muntané J, de la Mata M. Adjuvant chemotherapy for prevention of recurrence of invasive hepatocellular carcinoma after orthotopic liver transplantation. Transplant Proc. 2006;38:2495-2498.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 20]  [Cited by in F6Publishing: 21]  [Article Influence: 1.2]  [Reference Citation Analysis (0)]
88.  Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-390.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 9016]  [Cited by in F6Publishing: 9673]  [Article Influence: 604.6]  [Reference Citation Analysis (1)]
89.  Saab S, McTigue M, Finn RS, Busuttil RW. Sorafenib as adjuvant therapy for high-risk hepatocellular carcinoma in liver transplant recipients: Feasibility and efficacy. Exp Clin Transplant. 2010;8:307-313.  [PubMed]  [DOI]  [Cited in This Article: ]
90.  Bruix J, Takayama T, Mazzaferro V, Chau GY, Yang J, Kudo M, Cai J, Poon RT, Han KH, Tak WY, Lee HC, Song T, Roayaie S, Bolondi L, Lee KS, Makuuchi M, Souza F, Berre MA, Meinhardt G, Llovet JM; STORM investigators. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): A phase 3, randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2015;16:1344-1354.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 558]  [Cited by in F6Publishing: 692]  [Article Influence: 76.9]  [Reference Citation Analysis (0)]
91.  El-Khoueiry J, Qin S, Merle P, Granito A, Huang YH, Bodoky G, Pracht M, Yokosuka O, Rosmorduc O, Breder V, Gerolami R, Masi G, Ross PJ, Song T, Bronowicki JP, Ollivier-Hourmand I, Kudo M, Cheng AL, Llovet JM, Finn RS, LeBerre MA, Baumhauer A, Meinhardt G, Han G. RESORCE Investigators. Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): A randomized, double-blind, placebo-controlled, phase 3 trial.. Lancet. 2017;389:56-66.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 2160]  [Cited by in F6Publishing: 2446]  [Article Influence: 349.4]  [Reference Citation Analysis (0)]
92.  El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Hsu C, Kim TY, Choo SP, Trojan J, Welling J, TH RD, Kang YK, Yeo YK, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 2017;389:2492-2502.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 2536]  [Cited by in F6Publishing: 2972]  [Article Influence: 424.6]  [Reference Citation Analysis (1)]
93.  Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial. Lancet. 2018;391:1163-1173.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 3128]  [Cited by in F6Publishing: 3217]  [Article Influence: 536.2]  [Reference Citation Analysis (0)]
94.  Mínguez B, Hoshida Y, Villanueva A, Toffanin S, Cabellos L, Thung S, Mandeli J, Sia D, April C, Fan JB, Lachenmayer A, Savic R, Roayaie S, Mazzaferro V, Bruix J, Schwartz M, Friedman SL, Llovet JM. Gene-expression signature of vascular invasion in hepatocellular carcinoma. J Hepatol. 2011;55:1325-1331.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 105]  [Cited by in F6Publishing: 113]  [Article Influence: 8.7]  [Reference Citation Analysis (0)]
95.  Ke K, Chen G, Cai Z, Huang Y, Zhao B, Wang Y, Liao N, Liu X, Li Z, Liu J. Evaluation and prediction of hepatocellular carcinoma prognosis based on molecular classification. Cancer Manag Res. 2018;10:5291-5302.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 13]  [Cited by in F6Publishing: 16]  [Article Influence: 2.7]  [Reference Citation Analysis (0)]