Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn’s disease

Table 5 Comparison between 50 and 80% Crohn’s Disease Endoscopic Index of Severity reduction from baseline to week 14 as predictors of long-term mucosal healing

CDEIS reduction	Sensitivity (95%CI)	Specificity (95%CI)	PPV (95%CI)	NPV (95%CI)	LR+ (95%CI)	LR- (95%CI)
50%	85 (66%-96%)	66 (48%-81%)	66 (54%-76%)	85 (69%-93%)	2.5 (1.5-4)	0.23 (0.09-0.57)
80%	59 (39%-77%)	91 (77%-98%)	84 (63%-94%)	74 (65%-82%)	6.9 (2.24-21)	0.45 (0.28-0.72)

CDEIS: Crohn's Disease Endoscopic Index of Severity; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio.