Fungal dysbiosis predicts the diagnosis of pediatric Crohn’s disease
Mohammad I El Mouzan, Ahmad A Al Sarkhy, Department of Pediatrics, King Saud University, Riyadh 11461, Saudi Arabia
Kirill S Korolev, Rajita Menon, Bioinformatics Program, Boston University, Boston, MA 02215, United States
Mohammad A Al Mofarreh, Al Mofarreh PolyClinic, Riyadh 11423, Saudi Arabia
Harland S Winter, MassGeneral Hospital for Children, Boston, MA 02114, United States
Scot E Dowd, MRDNA, Shallowater, TX 79363, United States
Ahmad M Al Barrag, Department of Microbiology, King Saud University, Riyadh 11461, Saudi Arabia
Asaad A Assiri, Department of Pediatrics, Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh 11461, Saudi Arabia
Author contributions: El Mouzan MI and Winter HS contributed to the conception and design of the study; Al Mofarreh MA, Al Sarkhy AA, Assiri AA and Al Barrag AM contributed to data acquisition and samples’ storage; Dowd SE performed DNA extraction and fungal sequencing; Korolev KS and Menon R performed the biostatistics and bioinformatics; El Mouzan MI drafted the manuscript and all co-authors contributed to reviewing, editing and giving approval of the final manuscript.
Institutional review board statement: The manuscript is part of the study of the characteristics of inflammatory bowel disease in Saudi children approved by the IRB of the College of Medicine, King Saud University (No: 10/2647/IRB dated 29/6/2010).
Informed consent statement: Parents and/or children gave consent and/or assent to participate in the study before enrollment.
Conflict-of-interest statement: All authors declare no conflict of interest related to this study.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement - checklist items
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mohammad I El Mouzan, MD, Professor and Consultant Pediatrician, Department of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. firstname.lastname@example.org
Telephone: +966-55-5479281 Fax: +966-11-4679364
Received: June 29, 2018
Peer-review started: July 2, 2018
First decision: July 12, 2018
Revised: September 3, 2018
Accepted: October 5, 2018
Article in press: October 5, 2018
Published online: October 21, 2018