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Copyright ©The Author(s) 2018.
World J Gastroenterol. Apr 14, 2018; 24(14): 1521-1530
Published online Apr 14, 2018. doi: 10.3748/wjg.v24.i14.1521
Table 2 Main studies exploring the effect of gluten free diet in irritable bowel syndrome
Ref.CountryPopulationOutcome
Wahnschaffe et al[67], 2001Germany102 IBS-DStool frequency/bowel movement improved in DQ2-8 positive subjects
Aziz et al[68], 2016United Kingdom40 IBS-DA 6-wk GFD reduced symptoms in 70%
Vazquez-Roque et al[69], 2013United States45 IBS-DStool frequency/bowel movement reduced in patients under GFD
Di Sabatino et al[5], 2015Italy59 IBS with self-diagnosis of NCGSA challenge with 4 g/d of gluten worsened symptoms compared to placebo
Shahbazkhani et al[70], 2015Iran72 IBSWorsening of intestinal symptoms with gluten compared to placebo
Zanwar et al[71], 2016India60 IBSA 4-wk GFD improved a visual-analogue scale of symptoms
Elli et al[72], 2016Italy140 IBS with self-diagnosis of NCGSOnly the 14% showed a response to GFD as well as challenge test
Barmeyer et al[73], 2017Germany34 IBSThe 34% showed clinical improvement to GFD and continued for one year

Citation: Losurdo G, Principi M, Iannone A, Amoruso A, Ierardi E, Di Leo A, Barone M. Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm. World J Gastroenterol 2018; 24(14): 1521-1530