Published online Apr 14, 2018. doi: 10.3748/wjg.v24.i14.1521
Peer-review started: March 9, 2018
First decision: March 14, 2018
Revised: March 27, 2018
Accepted: March 31, 2018
Article in press: March 31, 2018
Published online: April 14, 2018
Core tip: Non celiac gluten sensitivity is an expanding field of investigation within gluten-related disorders. Similarly to celiac disease, it shows a systemic involvement, therefore several extra-intestinal manifestations have been hypothesized and investigated in many studies. They may involve many districts and have neurological/psychiatric, dermatological, rheumatologic and nutritional implications. Moreover, the possibility of association with other autoimmune diseases should not be underestimated. However, the large data amount from the literature often requires to be supported by evidence-based agreements.