Differential analysis of lymph node metastasis in histological mixed-type early gastric carcinoma in the mucosa and submucosa

Table 3 Clinicopathologic features of mucosa-confined early gastric carcinoma according to histological type n (%)

Variable	MT, n = 17	Pure U, n = 49	Pure D, n = 99	P value	P (Bonferroni corrected)
Age (yr)				0.028	MT vs PU, 0.525
≤ 60	10 (58.8)	33 (67.3)	44 (44.4)		MT vs PD, 0.272
> 60	7 (41.2)	16 (32.7)	55 (55.6)		PU vs PD, 0.009
Gender				0.004	MT vs PU, 0.151
Male	7 (41.2)	30 (61.2)	77 (77.8)		MT vs PD, 0.002
Female	10 (58.8)	19 (38.8)	22 (22.2)		PU vs PD, 0.034
Tumor size (cm)	2.1 ± 1.1	1.9 ± 1.2	1.9 ± 1.2	0.802
Location				0.003	MT vs PU, 0.759
U	1 (5.9)	4 (8.2)	29 (29.3)		MT vs PD, 0.042
M/L	16 (94.1)	45 (91.8)	70 (70.7)		PU vs PD, 0.004
Gross type				< 0.001	MT vs PU, 0.507
Elevated	4 (23.5)	8 (16.3)	51 (51.5)		MT vs PD, 0.033
Flat/depressed	13 (76.5)	41 (83.7)	48 (48.5)		PU vs PD, < 0.001
Ulcer				0.015	MT vs PU, 0.490
Absent	6 (35.3)	22 (44.9)	64 (64.6)		MT vs PD, 0.022
Present	11 (64.7)	27 (55.1)	35 (35.4)		PU vs PD, 0.022
H. pylori infection				0.025	MT vs PU, 0.015
Absent	1 (5.9)	18 (36.7)	22 (22.2)		MT vs PD, 0.119
Present	16 (94.1)	31 (63.3)	77 (77.8)		PU vs PD, 0.061
LV invasion				0.589
Absent	17 (100.0)	47 (95.9)	97 (98.0)
Present	0 (0)	2 (4.1)	2 (2.0)
LNM				0.016	MT vs PU, 0.739
Absent	14 (82.4)	42 (85.7)	96 (97.0)		MT vs PD, 0.012
Present	3 (17.6)	7 (14.3)	3 (3.0)		PU vs PD, 0.010

MT: Mixed-type; PU: Pure undifferentiated; PD: Pure differentiated; U: Upper; M/L: Middle/lower; LV: Lymphovascular; LNM: Lymph node metastasis.