Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale

doi:10.3748/wjg.v23.i19.3546

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2017; 23(19): 3546-3555
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3546

Table 2 Characteristics on the oropharyngeal pH-monitoring, manometry and endoscopy between laparoscopic Nissen fundoplication and proton pump inhibitor groups

Characteristic/examination parameter	LNF	PPI	P value
Oropharyngeal pH-monitoring
Acid exposure (upright, %)	11.77 ± 18.95	8.49 ± 15.66	0.416
Acid exposure (supine, %)	4.25 ± 12.79	3.28 ± 7.92	0.182
Number of reflux events (upright)	53.84 ± 97.48	34.93 ± 65.35	0.195
Number of reflux events (supine)	7.44 ± 18.42	5.14 ± 9.22	0.232
Ryan score (upright)	335.13 ± 491.08	274.57 ± 459.10	0.617
Ryan score (supine)	8.98 ± 16.18	7.23 ± 7.81	0.217
High-resolution Manometry
LES pressure (mmHg)	11.78 ± 8.07	14.84 ± 9.73	0.236
UES pressure (mmHg)	43.8 ± 28.33	67.08 ± 42.51	0.045¹
Dysperistalsis	3 (9.7)	10 (25.6)	0.090¹
Hiatal hernia	24 (77.4)	33 (84.6)	0.449
GI endoscopy
Esophagitis (grade A)	10 (32.2)	10 (25.6)	0.549
Esophagitis (grade B)	3 (9.7)	2 (5.1)	0.470
Hiatal hernia	16 (51.6)	30 (76.9)	0.027¹

¹Represent statistical significant P values (P < 0.05). Values are given as mean ± SD or n (%). LNF: Laparoscopic Nissen fundoplication; PPI: Proton pump inhibitor; LES: Lower esophageal sphincter; UES: Upper esophageal sphincter.

Citation: Zhang C, Hu ZW, Yan C, Wu Q, Wu JM, Du X, Liu DG, Luo T, Li F, Wang ZG. Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale. World J Gastroenterol 2017; 23(19): 3546-3555
URL: https://www.wjgnet.com/1007-9327/full/v23/i19/3546.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i19.3546