Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody

Figure 5 Relationship between the two types of CagA antibody ELISA titers. Dotted lines indicate the cut off values (6.25 U/mL for Western-type CagA ELISA and 45.0 U/mL for East Asian-type CagA ELISA). A: Scatter plot of uninfected subjects. Of the 107 Helicobacter pylori (H. pylori) uninfected subjects, 104 subjects (97.2%) were negative by Western-type CagA ELISA and 100 subjects (93.5%) by East Asian-type CagA ELISA; B: Scatter plots of infected subjects. Of the 110 H. pylori infected subjects, 69 (62.7%) subjects were positive by Western-type CagA ELISA and 78 (70.9%) by East Asian-type CagA ELISA; C: Scatter plot of Western-type cagA H. pylori infected subjects. Of the 38 subjects infected with western-type cagA H. pylori, 32 subjects (84.2%) were positive by Western-type CagA ELISA and 25 subjects (65.8%) were positive by East Asian-type CagA ELISA; D: Scatter plot of East Asian-type cagA H. pylori infected subjects. Of the 72 subjects infected with East Asian-type cagA H. pylori, 53 subjects (73.6%) were positive by East Asian-type CagA ELISA and 37 subjects (51.4%) were positive by Western-type CagA ELISA.