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Copyright ©The Author(s) 2016.
World J Gastroenterol. Dec 28, 2016; 22(48): 10482-10501
Published online Dec 28, 2016. doi: 10.3748/wjg.v22.i48.10482
Figure 7
Figure 7 Example of a purely pressure-driven fibrosis: Experimental liver congestion over 4 mo causes significant non-inflammatory liver fibrosis. The caval vein was subphrenically partly clamped in Wistar rats to cause hepatic congestion. A: Illustrates LS in male Wistar rats (n = 6) in control, sham operated and clamped group immediately after onset of congestion; B: Histological analysis of liver tissue sections shows a significant development of fibrosis after 4 mo of congestion in the clamped but not sham operated animals. (data from [27]), bP < 0.01. LS: Liver stiffness.

Citation: Mueller S. Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis. World J Gastroenterol 2016; 22(48): 10482-10501