TCF7L2 rs7903146 polymorphism is associated with gastric cancer: A case-control study in the Venezuelan population

doi:10.3748/wjg.v22.i28.6520

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2016; 22(28): 6520-6526
Published online Jul 28, 2016. doi: 10.3748/wjg.v22.i28.6520

Table 2 Association of TCF7L2 rs7903146 and rs12255372 polymorphisms with gastric cancer n (%)

SNP	Risk allele	HWE (control), P value	Inheritance model	Genotype	Control	Gastric cancer	OR (95%CI)¹	P value¹
rs7903146	T	0.741			n = 129	n = 122
				CC	73 (56.6)	56 (45.9)	1
			Codominant	CT	49 (38.0)	48 (39.3)	1.30 (0.75–2.25)	0.345
				TT	7 (5.4)	18 (14.8)	3.61 (1.36–9.61)	0.010
			Dominant	CC	73 (56.6)	56 (45.9)	1
				CT + TT	56 (43.4)	66 (54.1)	1.58 (0.94–2.64)	0.082
			Recessive	CC + CT	122 (94.6)	104 (85.2)	1
				TT	7 (5.4)	18 (14.8)	3.11 (1.22–7.92)	0.017
rs12255372	T	0.053			n = 129	n = 117
				GG	85 (65.9)	78 (66.7)	1
			Codominant	GT	35 (27.1)	32 (27.3)	1.06 (0.59–1.92)	0.841
				TT	9 (7.0)	7 (6.0)	1.11 (0.38–2.25)	0.849
			Dominant	GG	85 (65.9)	78 (66.7)	1
				GT + TT	44 (34.1)	39 (33.3)	1.06 (0.61–1.83)	0.839
			Recessive	GG + GT	120 (93.0)	110 (94.0)	1
				TT	9 (7.0)	7 (6.0)	1.02 (0.36–2.90)	0.972

¹Adjusted by age and gender; Statistical power (1-β) was calculated for all observed P values. HWE: Hardy-Weinberg equilibrium; SNP: Single nucleotide polymorphism.

Citation: Torres K, Labrador L, Valderrama E, Chiurillo MA. TCF7L2 rs7903146 polymorphism is associated with gastric cancer: A case-control study in the Venezuelan population. World J Gastroenterol 2016; 22(28): 6520-6526
URL: https://www.wjgnet.com/1007-9327/full/v22/i28/6520.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i28.6520