Letters To The Editor
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2016; 22(15): 4071-4072
Published online Apr 21, 2016. doi: 10.3748/wjg.v22.i15.4071
Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication
Hakan Demirci, Kadir Ozturk, Omer Kurt
Hakan Demirci, Kadir Ozturk, Omer Kurt, Department of Gastroenterology, Gulhane Military Medical Academy, 06010 Ankara, Turkey
Author contributions: Demirci H designed research, performed research and wrote the paper; Ozturk K contributed new reagents or analytic tools; and Kurt O analyzed data.
Conflict-of-interest statement: No conflict of interest
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hakan Demirci, Department of Gastroenterology, Gulhane Military Medical Academy, Etlik, 06010 Ankara, Turkey. hakandemircigata@yahoo.com
Telephone: +90-532-5140028 Fax: +90-312-3044070
Received: December 15, 2015
Peer-review started: December 16, 2015
First decision: December 30, 2015
Revised: January 5, 2016
Accepted: January 30, 2016
Article in press: January 30, 2016
Published online: April 21, 2016

Abstract

We read the article “Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori (H. pylori) eradication: A prospective single-center study from China” written by Wang et al with great interest. It is reported in American and European guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended. Patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study. But patients who used probiotics and antioxidant vitamins such as vitamins C and E were not excluded.

Key Words: Helicobacter pylori, Erdication rates, Telephone based education

Core tip: We read the article “Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori (H. pylori) eradication: A prospective single-center study from China” written by Wang et al. It is reported in guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended. Patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study.



TO THE EDITOR

We read the article “Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication: A prospective single-center study from China” written by Wang et al[1] with great interest. The authors investigated the effects of daily telephone based re-education before taking medicine for the eradication of Helicobacter pylori (H. pylori) on the compliance and the eradication rate. We thank the authors for their contribution of well-presented study. We believe that these findings of current study will encourage further studies for H. pylori eradication.

H. pylori remains one of the most widespread worldwide human infections and is associated with upper gastrointestinal states, including peptic ulcer disease, chronic gastritis, and gastric malignancy[2]. The prevalence of H. pylori is closely related to socioeconomic status. This infection is more prevalent in developing countries than in Western countries. Wang et al[1] informed us that in their study that the daily TRE before taking medicine had no significant impact on the patients’ compliance, satisfaction, or H. pylori eradication, but reduced the rate of adverse events. However, we believe that some points that should be emphasized in the study.

The authors reported in the present study that they had used diagnosis of H. pylori infection by at least one of the following methods: 13C-urea breath test, histology, rapid urease test or bacterial culture. It is reported in American and European guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended[2,3]. Hence, we consider that the number of H. pylori positive patients is different from that found in this present study. It is obviously seen that this distinction in number of H. pylori positive patients will impress the results of the study.

Additionally, patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study. But patients who used probiotics and antioxidant vitamins such as vitamins C and E were not excluded. It has been thought that vitamins C and E break the microenvironment created by H. pylori or directly inhibit bacteria. Vitamin C can inactivate the urease enzyme, which allows the endurance of H. pylori and the colonization of the gastric mucosa at a low pH. Thus, vitamin C may inhibit the spread, growth, and colonization of H. pylori in the early periods of infection[4]. Probiotics reduce the adverse effects of H. pylori eradication treatment, this could help increasing the adherence of patients to treatment and could increase the eradication rate. Probiotics may also inhibit the growth of H. pylori, stimulate an immunological response and reduce the inflammatory effects of infection[5]. It is clearly seen that this factors can change the results of the study.

Footnotes

P- Reviewer: Chmiela M, Du YQ, Ozen H, Said Z S- Editor: Gong ZM L- Editor: A E- Editor: Zhang DN

References
1.  Wang CH, Liao ST, Yang J, Li CX, Yang YY, Han R, Chen DF, Lan CH. Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication: A prospective single-center study from China. World J Gastroenterol. 2015;21:11179-11184.  [PubMed]  [DOI]
2.  Chey WD, Wong BC. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102:1808-1825.  [PubMed]  [DOI]
3.  Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T. Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut. 2012;61:646-664.  [PubMed]  [DOI]
4.  Demirci H, Uygun İlikhan S, Öztürk K, Üstündağ Y, Kurt Ö, Bilici M, Köktürk F, Uygun A. Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turk J Gastroenterol. 2015;26:456-460.  [PubMed]  [DOI]
5.  Homan M, Orel R. Are probiotics useful in Helicobacter pylori eradication? World J Gastroenterol. 2015;21:10644-10653.  [PubMed]  [DOI]